發(fā)布時間：2018-04-09 13:53

  本文選題：獲得性免疫缺陷綜合征　切入點：肺結(jié)核　出處：《中國感染與化療雜志》2017年03期

【摘要】：目的分析獲得性免疫缺陷綜合征(AIDS)合并肺結(jié)核患者的流行病學(xué)及臨床特征。方法采用回顧性研究方法,收集2011年1月-2015年12月在上海市公共衛(wèi)生臨床中心診斷為AIDS合并肺結(jié)核患者的病歷資料,并通過門診隨訪和電話隨訪,了解患者的預(yù)后情況。運用SPSS 22.0軟件,對其特征進行描述性分析。結(jié)果 359例AIDS合并肺結(jié)核患者中男325例,女34例,30~44歲所占比例最大,42.6%患者出現(xiàn)發(fā)現(xiàn)延誤;臨床癥狀以發(fā)熱、咳嗽、體重下降較多見,咯血少見,多數(shù)研究對象兩肺受累,病變范圍≥3個肺野,空洞少見;T-SPOT陽性率偏低,50.7%患者首次檢查CD4~+T淋巴細胞計數(shù)≤50/μL;69例患者痰結(jié)核菌藥敏結(jié)果顯示,43.5%出現(xiàn)耐藥;已知抗病毒狀態(tài)中的患者93.2%已經(jīng)進行了抗病毒治療;282例合并肺外結(jié)核,合并癥及機會性感染以中樞神經(jīng)系統(tǒng)感染、梅毒、乙型或丙型病毒性肝炎、肺部感染、藥物性肝損等為主;333例已知預(yù)后情況的患者中53例死亡,其中79.2%在6個月內(nèi)死亡。結(jié)論 AIDS合并肺結(jié)核患者年輕患者比例大,影像學(xué)表現(xiàn)不典型,T-SPOT陽性率偏低,首次CD4~+T淋巴細胞計數(shù)較低,多數(shù)患者合并肺外結(jié)核,合并癥和機會性感染較多,患者多在6個月內(nèi)死亡。
[Abstract]:Objective to analyze the epidemiological and clinical features of acquired immunodeficiency syndrome (AIDS) complicated with pulmonary tuberculosis.Methods A retrospective study was conducted to collect the medical records of AIDS patients with pulmonary tuberculosis diagnosed in Shanghai Public Health Clinical Center from January 2011 to December 2015. The prognosis of the patients was analyzed by out-patient follow-up and telephone follow-up.SPSS 22. 0 software is used to analyze its characteristics.Results there were 325 males and 34 females aged 30 to 44 years old in AIDS with pulmonary tuberculosis. The clinical symptoms were fever, cough, weight loss, hemoptysis and hemoptysis.The extent of lesion was more than 3 lung fields, and the positive rate of T-spot was low in 50.7% of the patients. In 69 patients with CD4 ~ T lymphocyte count 鈮，

本文編號：1726705