本文選題：血脂　切入點(diǎn)：糖尿病前期　出處：《蘇州大學(xué)》2015年碩士論文

【摘要】：研究背景目前國(guó)內(nèi)尚未見有關(guān)大樣本的蒙古族人群血脂與糖代謝異常發(fā)病關(guān)系的前瞻性研究的相關(guān)報(bào)道。研究目的探討血脂指標(biāo)(包括總膽固醇、甘油三酯、低密度脂蛋白膽固醇和高密度脂蛋白膽固醇4個(gè)指標(biāo))與糖尿病前期、糖尿病及糖代謝異常之間的關(guān)系。研究對(duì)象與方法1.基線調(diào)查:2002-2003年,選擇內(nèi)蒙古科左后旗和奈曼旗兩個(gè)鄉(xiāng)32個(gè)行政村為研究地點(diǎn),選擇20歲及以上蒙古族居民共2589人為研究對(duì)象,簽署知情同意書后開展問卷調(diào)查、體格檢查、血壓測(cè)量和血標(biāo)本的采集;并且由經(jīng)過嚴(yán)格培訓(xùn)的實(shí)驗(yàn)室人員進(jìn)行血脂和胰島素等指標(biāo)的檢測(cè)。2.隨訪調(diào)查:2013-2014年對(duì)基線調(diào)查時(shí)20-65歲之間血糖正常(空腹血糖6.1mmol/L)的研究對(duì)象進(jìn)行隨訪調(diào)查,內(nèi)容包括:收集人口統(tǒng)計(jì)學(xué)、疾病史和生活方式等傳統(tǒng)危險(xiǎn)因素資料;進(jìn)行體格檢查;檢測(cè)空腹血糖和進(jìn)行口服葡萄糖耐量試驗(yàn)。3.統(tǒng)計(jì)分析:采用Epidata3.1軟件建立數(shù)據(jù)庫(kù),所有調(diào)查表經(jīng)過雙錄入后進(jìn)行核對(duì),應(yīng)用SAS 9.2軟件進(jìn)行統(tǒng)計(jì)分析,檢驗(yàn)水準(zhǔn)α設(shè)為0.05。研究結(jié)果共有1760人納入數(shù)據(jù)分析,其中血糖正常者1090例,糖尿病前期者513例,糖尿病患者157例。1.糖尿病的累積發(fā)病率為8.92%,發(fā)病密度為81.97/萬人年;糖尿病前期的累積發(fā)病率為29.15%,發(fā)病密度為267.85/萬人年;糖代謝異常的累積發(fā)病率為38.07%,發(fā)病密度為349.82/萬人年。2.蒙古族人群糖尿病前期、糖尿病和糖代謝異常的發(fā)病率無明顯性別差異(均P0.05)。在30,30-39,40-49以及≥50歲的人群中,糖尿病前期和糖代謝異常的累積發(fā)病率在男性、女性以及總?cè)巳褐芯S著年齡的增加而增加(均P0.05);糖尿病的累積發(fā)病率在女性和總?cè)巳褐芯S著年齡的增加而增加(均P0.05)。3.與血糖正常者相比,糖尿病前期者基線TC、TG和LDL-C水平均較高;與血糖正常者相比,糖尿病患者和糖代謝異常者TC、TG和LDL-C水平均較高,HDL-C水平較低;與糖尿病前期者相比,糖尿病患者的TG水平較高,HDL-C水平較低。4.總?cè)巳褐?經(jīng)多因素調(diào)整后,與TG
[Abstract]:Background at present, there are no prospective reports on the relationship between blood lipids and glycometabolism in large samples of Mongolian population.Objective to investigate the relationship between serum lipids (including total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol) and diabetes mellitus and abnormal glucose metabolism.Object and method 1.The baseline survey: in 2002-2003, 32 administrative villages of Kezuohou Banner and Naiman Banner of Inner Mongolia were selected as the study sites, and 2589 Mongolian residents aged 20 and above were selected as the research subjects. After signing the informed consent letter, they conducted a questionnaire survey and a medical examination.Blood pressure was measured and blood samples were collected, and blood lipids and insulin were measured by trained laboratory personnel. 2. 2.Follow-up survey: in 2013-2014, subjects aged 20-65 years with normal blood glucose (fasting blood glucose 6.1 mmol / L) were followed up in the baseline survey, including collecting data on traditional risk factors, such as demography, history of disease and lifestyle;Fasting blood glucose and oral glucose tolerance test. 3.Statistical analysis: Epidata3.1 software was used to establish the database, all the questionnaires were checked after double input, and the SAS 9.2 software was used for statistical analysis. The test level was set to 0.05.A total of 1760 people were included in the data analysis, including 1090 patients with normal blood glucose, 513 patients with prediabetes and 157 patients with diabetes.The cumulative incidence of diabetes was 8.92, the incidence density was 819.7 / 10, the prediabetic cumulative incidence was 29.155.The cumulative incidence of abnormal glucose metabolism was 38.07, and the incidence density was 349.82 / 10 000.There was no significant difference in the incidence of diabetes mellitus and abnormal glucose metabolism in Mongolian population (all P 0.05).The cumulative incidence of prediabetes and abnormal glucose metabolism was found in men aged 30 to 39 years and older than 50 years.Compared with normal blood glucose, the baseline TCTG and LDL-C levels were higher in prediabetic patients, higher in diabetic patients and abnormal glucose metabolism patients, and lower in prediabetic patients.The TG level of diabetic patients is higher and HDL-C level is lower. 4. 4.Among the total population, after multifactorial adjustment, the relationship between TG and TG
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R587.1

【參考文獻(xiàn)】

相關(guān)博士學(xué)位論文 前2條

1 付朝偉;農(nóng)村社區(qū)成人2型糖尿病（德清隊(duì)列）研究[D];復(fù)旦大學(xué);2010年

2 薛海峰;中國(guó)成人腹型肥胖與糖尿病發(fā)病關(guān)系的前瞻性隊(duì)列研究[D];北京協(xié)和醫(yī)學(xué)院;2014年

，

本文編號(hào)：1726700