本文選題：痛風(fēng)　切入點：SLC2A9基因　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:目前認(rèn)為認(rèn)知功能的損害可能與痛風(fēng)、腎臟疾病、高血壓等臨床疾病緊密相關(guān),以上疾病也是痛風(fēng)患者中常見的多發(fā)的并發(fā)癥。為何要研究此課題,是因為可以解決新疆地域男性病人的一些對普通和特殊認(rèn)知功能和對某些基因比如與SLC2A9基因SNP的之間的關(guān)聯(lián)。方法:選取新疆漢族地區(qū)男性原發(fā)性痛風(fēng)患者和健康體檢者分別200名,記錄他們的基本資料,比如他們的腰臀比、身高、重量、歲數(shù)、健康指數(shù)(BMI)、受教育程度、收縮壓和舒張壓、一般生化資料,使用某些探針如TaqMan測試法,使用臨床上常見的特殊心理量表,比如說以下幾種量表:WAIS(韋氏成人智力量表)、MMSE(簡易精神狀態(tài)檢查量表)、MoCA(蒙特利爾認(rèn)知評估表)進行檢測。因原發(fā)性痛風(fēng)的SLC2A9基因與許多多態(tài)性基因相關(guān)連比如說rs3733591,rs11722228和rs5568674位點進行多態(tài)性基因檢測;同時對以上所有基因結(jié)果行統(tǒng)計學(xué)分析。結(jié)果:(1)檢測SLC2A9基因中3個SNP位點:其中rs3733591和rs11722228位點基因多態(tài)性與痛風(fēng)易感性相關(guān)(P=0.0170,P=0.0005)。(2)病例組與健康體檢者的某些指標(biāo)的統(tǒng)計學(xué)數(shù)值是否會形成一些顯著的差異(P0.05),比較上述兩組同時使用MoCA量表,此表的內(nèi)容包含不同指標(biāo)的分?jǐn)?shù),從而可以檢測人類的后天的抽象能力、顯示語言是否有統(tǒng)計學(xué)差異(P0.05)。(3)rs3733591(CC/CT/TT),rs11722228(CC/CT/TT)和rs55686745(CC/CT/TT)各基因型之間尿酸無明顯差異(P0.05)。(4)回歸分析揭示:SLC2A9基因中rs3733591,rsll722228和rs55686745基因多態(tài)性與男性痛風(fēng)患者認(rèn)知功能不相關(guān)(P0.05)。結(jié)論:進行此項研究的人群是新疆漢族男性痛風(fēng)患者,將他們作為整體部分,從而深入的闡述了痛風(fēng)人群SLC2A9基因多態(tài)性與認(rèn)知功能關(guān)系的研究。
[Abstract]:Objective: it is believed that cognitive impairment may be closely related to gout, kidney disease, hypertension and other clinical diseases. These diseases are also common complications in patients with gout.The reason for this research is that it can solve the relationship between common and special cognitive function of male patients in Xinjiang region and some genes such as SLC2A9 gene SNP.Methods: 200 male patients with primary gout and 200 healthy people in Xinjiang Han nationality were selected to record their basic data, such as waist-to-hip ratio, height, weight, age, health index and educational level.Systolic and diastolic blood pressure, general biochemical data, use of certain probes such as TaqMan test, use of clinical common special psychological scale,For example, the following scales: WAIS (Wechsler Adult Intelligence scale) MMSE (simple Mental State scale) were tested by MoCA (Montreal Cognitive Assessment scale).The SLC2A9 gene of primary gout was associated with many polymorphic genes, such as rs3733591, rs11722228 and rs5568674, and the results of all the above genes were analyzed statistically.Results: 1) three SNP loci in the SLC2A9 gene were detected. Among them, the polymorphism of rs3733591 and rs11722228 loci was associated with the susceptibility to gout.) the statistical values of some indexes in the case group and the healthy persons were significantly different (P 0.05, P < 0.05).Compared with the above two groups, using MoCA scale at the same time,The contents of this table contain scores of different indicators, which can measure human's acquired abstract ability.Conclusion: this study was conducted in Xinjiang Han male patients with gout, taking them as a whole, and then the relationship between SLC2A9 gene polymorphism and cognitive function of gout population was discussed.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R589.7

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