本文選題：支氣管哮喘　切入點(diǎn)：中性粒細(xì)胞-淋巴細(xì)胞比值　出處：《南方醫(yī)科大學(xué)學(xué)報(bào)》2017年01期

【摘要】：目的探討外周血中性粒細(xì)胞-淋巴細(xì)胞比值(neutrophil-lymphocyte ratio,NLR)和血小板-淋巴細(xì)胞比值(plateletlymphocyte ratio,PLR)在支氣管哮喘急性發(fā)作期患者中的變化及臨床意義。方法選取2013年1月~2016年5月期間確診的支氣管哮喘急性發(fā)作期患者262例為病例組及130例健康體檢者為正常對照組。根據(jù)其急性發(fā)作期病情嚴(yán)重程度,將哮喘患者分為危重組87例、非危重組175例。記錄病例組和健康對照組性別、年齡等臨床資料和血常規(guī)結(jié)果,并計(jì)算NLR和PLR。比較3組間中性粒細(xì)胞絕對值、淋巴細(xì)胞絕對值、血小板計(jì)數(shù)、NLR、PLR的差異,以ROC曲線評價(jià)各指標(biāo)對哮喘的診斷價(jià)值。結(jié)果各組間中性粒細(xì)胞絕對值、淋巴細(xì)胞絕對值、NLR、PLR差異具有統(tǒng)計(jì)學(xué)意義(P0.0001),各組血小板計(jì)數(shù)差異無統(tǒng)計(jì)學(xué)意義(P=0.971)。哮喘危重組淋巴細(xì)胞絕對值低于哮喘非危重組、健康對照組(P0.0001),而中性粒細(xì)胞絕對值、NLR、PLR顯著高于哮喘危重組、健康對照組(P0.0001)。哮喘非危重組中性粒細(xì)胞絕對值、淋巴細(xì)胞絕對值、NLR、PLR與健康對照組相比差異無統(tǒng)計(jì)學(xué)意義(P0.05)。中性粒細(xì)胞絕對值、淋巴細(xì)胞絕對值、NLR、PLR對支氣管哮喘急性發(fā)作期危重患者診斷的曲線下面積分別為0.802、0.784、0.873、0.795(均P0.01)。NLR診斷支氣管哮喘急性發(fā)作期危重患者的最佳臨界值為2.58,敏感度為82.8%,特異度為81.1%。結(jié)論支氣管哮喘患者外周血NLR、PLR均升高,對支氣管哮喘的診斷和病情監(jiān)測有一定臨床指導(dǎo)意義。
[Abstract]:Objective to investigate the changes and clinical significance of neutrophil-lymphocyte ratio (neutrophil-lymphocyte) and platelet-lymphocyte ratio (PLR) in patients with acute asthma. 262 patients with acute episode of bronchial asthma were diagnosed as case group and 130 healthy persons as normal control group. According to the severity of acute attack of bronchial asthma, The patients with asthma were divided into two groups: 87 patients with critical recombination and 175 patients with non-risk recombinant. The clinical data and blood routine results such as sex, age and NLR were recorded, and the absolute values of neutrophils and lymphocytes were compared among the three groups. The ROC curve was used to evaluate the diagnostic value of each index in asthma. Results the absolute value of neutrophils in each group was determined. The absolute value of lymphocytes was significantly different from that of NLRN PLR (P 0.0001), but the platelet count of each group had no significant difference. The absolute value of recombinant lymphocytes in asthma was lower than that in non-risk asthmatic recombination, and there was no significant difference in platelet count in each group. The absolute value of neutrophils and neutrophils in healthy control group was significantly higher than that in asthma risk group, and the absolute value of non-risk recombinant neutrophil in healthy control group was significantly higher than that in asthmatic risk group. There was no significant difference in lymphocyte absolute value between NLRN PLR and healthy control group (P 0.05). The area under the curve for the diagnosis of critical patients with acute attack of bronchial asthma was 0.802 / 0.784 / 0.873 / 0.795 (respectively) (the best critical value of P0.01).NLR for the diagnosis of critical patients with acute attack of bronchial asthma was 2.58, the sensitivity was 82.8 and the specificity was 82.8%). Conclusion Peripheral blood NLR PLR increased in patients with bronchial asthma. It has certain clinical guiding significance for the diagnosis and condition monitoring of bronchial asthma.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院檢驗(yàn)科//河南省檢驗(yàn)醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室//鄭州大學(xué)醫(yī)學(xué)檢驗(yàn)系;
【基金】：國家自然科學(xué)基金(81501715) 河南省科技攻關(guān)項(xiàng)目(162102310142,152102410067)~~
【分類號】：R562.25

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