本文選題：葡萄糖吸收　切入點(diǎn)：鈣離子通道　出處：《中國(guó)糖尿病雜志》2017年05期 　論文類(lèi)型：期刊論文

【摘要】：迄今為止葡萄糖在小腸黏膜的吸收機(jī)制已被系統(tǒng)地闡明和接受,即經(jīng)典的鈉葡萄糖同向轉(zhuǎn)運(yùn)體(SGLT1)介導(dǎo)的主動(dòng)轉(zhuǎn)運(yùn)機(jī)制。此外,當(dāng)腸腔葡萄糖濃度高于SGLT1的轉(zhuǎn)運(yùn)飽和度時(shí),葡萄糖轉(zhuǎn)運(yùn)蛋白2(GluT2)可能一過(guò)性易位于小腸黏膜上皮細(xì)胞頂膜來(lái)參與葡萄糖的異化擴(kuò)散吸收,但小腸黏膜上皮細(xì)胞葡萄糖吸收的調(diào)節(jié)機(jī)制仍然不是完全清楚。近年來(lái)鈣離子通道(CRAC)及細(xì)胞內(nèi)鈣信號(hào)對(duì)葡萄糖的吸收調(diào)節(jié)作用備受關(guān)注,二者可通過(guò)調(diào)節(jié)腸道葡萄糖轉(zhuǎn)運(yùn)體SGLT1和GluT2的表達(dá)及功能來(lái)調(diào)節(jié)小腸葡萄糖的吸收。本文以CRAC及細(xì)胞內(nèi)鈣信號(hào)對(duì)小腸黏膜上皮細(xì)胞葡萄糖的吸收調(diào)節(jié)作用及其分子機(jī)制進(jìn)行論述,希望能為肥胖及其相關(guān)疾病的防治提供新的視野及潛在的新藥研發(fā)靶點(diǎn)。
[Abstract]:Up to now, the mechanism of glucose absorption in intestinal mucosa has been systematically elucidated and accepted, that is, the classical mechanism of active transport of sodium and glucose to the transporter SGLT1. In addition, when the concentration of glucose in intestinal cavity is higher than the saturation of transport of SGLT1, Glucose transporter 2 (GluT2) may be temporarily located in the apical membrane of small intestinal mucosal epithelium to participate in the dissimilatory diffusion and absorption of glucose. However, the regulation mechanism of glucose absorption in intestinal mucosal epithelial cells is still not fully understood. In recent years, the regulation of glucose absorption by intracellular calcium signal and calcium channel (CRAC) has attracted much attention. They can regulate the absorption of glucose by regulating the expression and function of intestinal glucose transporter SGLT1 and GluT2. In this paper, we discuss the regulation of glucose absorption by CRAC and intracellular calcium signal and its molecular mechanism. Hope to provide a new vision and potential new drug development targets for the prevention and treatment of obesity and related diseases.
【作者單位】： 遵義醫(yī)學(xué)院附屬醫(yī)院消化內(nèi)科;
【基金】：國(guó)家自然科學(xué)基金(31371167、No81570、81570477)
【分類(lèi)號(hào)】：R589.2

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本文編號(hào)：1573166