本文關(guān)鍵詞：具有多囊卵巢綜合征表型絕經(jīng)女性心血管疾病發(fā)病風險研究　出處：《中國實用婦科與產(chǎn)科雜志》2016年09期 　論文類型：期刊論文

  更多相關(guān)文章： 多囊卵巢綜合征 絕經(jīng) 心血管事件

【摘要】：目的探討具有多囊卵巢綜合征(PCOS)表型的絕經(jīng)女性心血管疾病的發(fā)生風險。方法以2005-01-01—2007-12-31于蘇州大學附屬第二醫(yī)院健康體檢的絕經(jīng)女性346例為研究對象,根據(jù)有無PCOS表型分為2組:PCOS表型組(57例)和非PCOS表型組(289例)。隨訪以電話隨訪為主,輔以住院隨訪、門診隨訪等。隨訪間歇為3個月,隨訪終點為主要不良心血管事件(MACE),隨訪截止日期為2014-12-31。生存率估算應(yīng)用Kaplan-Meier法,組間生存率曲線差異采用log-rank檢驗,應(yīng)用多變量Cox比例風險回歸分析MACE的獨立危險因素。結(jié)果非PCOS表型組有10例出現(xiàn)MACE,PCOS表型組有7例出現(xiàn)MACE。Kaplan-Meier曲線顯示PCOS表型組無MACE生存率顯著下降(χ2=4.754,P=0.023)。多變量Cox比例風險回歸分析發(fā)現(xiàn)高密度脂蛋白膽固醇(HDL-C)較低、超敏C反應(yīng)蛋白(hsCRP)較高和存在PCOS表型是MACE的獨立預(yù)測因素。結(jié)論 PCOS表型是絕經(jīng)女性發(fā)生心血管疾病的獨立危險因素,有助于進一步行危險分層,且提示PCOS與心血管疾病密切相關(guān)。
[Abstract]:Objective to investigate PCOS with polycystic ovary syndrome (PCOS). The risk of cardiovascular disease in menopausal women with phenotype was studied in 346 postmenopausal women who underwent physical examination in the second affiliated Hospital of Suzhou University from January to January 2007-12-31 2005. Elephant. PCOS phenotypes were divided into 2 groups according to the phenotype of PCOS: 57 cases of PCOS phenotype group and 289 cases of non-PCOS phenotype group. Telephone follow-up was the main follow-up followed by in-patient follow-up. Outpatient follow-up and so on. The interval of follow-up was 3 months, and the end point was major adverse cardiovascular events (MACEE). The deadline of follow-up was 2014-12-31. Kaplan-Meier method was used to estimate the survival rate, and the difference of survival curve between groups was evaluated by log-rank test. Multivariate Cox proportional risk regression analysis was used to analyze the independent risk factors of MACE. Results MACE was found in 10 cases of non-#en2# phenotypic group. In 7 cases of PCOS phenotypic group, MACE.Kaplan-Meier curve showed that the MACE free survival rate of PCOS phenotypic group decreased significantly (蠂 2 = 4.754). Multivariate Cox proportional risk regression analysis showed that HDL-C was lower than HDL-C in high density lipoprotein cholesterol (HDL-C). The high sensitivity C-reactive protein hsCRP and the presence of PCOS phenotype are independent predictors of MACE. Conclusion PCOS phenotype is an independent risk factor for cardiovascular disease in postmenopausal women. It is helpful for further risk stratification and suggests that PCOS is closely related to cardiovascular disease.
【作者單位】： 蘇州大學附屬第二醫(yī)院婦產(chǎn)科;無錫第四人民醫(yī)院婦產(chǎn)科;無錫市婦幼保健院婦產(chǎn)科;
【分類號】：R711.75;R54
【正文快照】： 多囊卵巢綜合征(PCOS)是一種復(fù)雜的內(nèi)分泌 及代謝異常疾病,以慢性無排卵(排卵功能紊亂或喪失)和高雄激素血癥為特征。隨著對PCOS研究的增多,發(fā)現(xiàn)PCOS不僅僅與不孕關(guān)系密切,而且與2型糖尿病、代謝綜合征以及心血管疾病的發(fā)生、發(fā)展相關(guān)[1-3]。既往有關(guān)PCOS與心血管疾病的研究,，

本文編號：1366695