本文關(guān)鍵詞：男性睪酮水平及中老年男性雄激素部分缺乏綜合征患病率分析　出處：《中國全科醫(yī)學(xué)》2016年30期 　論文類型：期刊論文

  更多相關(guān)文章： 睪酮 中老年男性雄激素部分缺乏綜合征 男人

【摘要】：背景隨著男性年齡增長,下丘腦-垂體-性腺軸功能逐漸衰退,因睪酮缺乏造成的中老年男性雄激素部分缺乏綜合征(PADAM)會導(dǎo)致腹部肥胖、2型糖尿病、代謝綜合征、心血管疾病、骨骼肌肉質(zhì)量下降、性功能減退、情緒抑郁和認知障礙等。目的探討男性睪酮水平及PADAM患病率變化。方法收集2011—2014年于溫州醫(yī)科大學(xué)附屬第一醫(yī)院體檢的符合納入標準的健康男性5 743例為研究對象。按照年齡分為20~歲組(142例)、30~歲組(1 261例)、40~歲組(2 346例)、50~歲組(1 339例)、60~歲組(552例)、70~85歲組(103例)。檢測并記錄所有研究對象睪酮水平。以20~歲組P10睪酮水平(11.1 nmol/L)作為閾值來判斷PADAM患病率。結(jié)果研究對象睪酮水平為15.14(16.87,25.05)nmol/L,年平均PADAM患病率為16.8%。睪酮水平與年齡呈負相關(guān)(rs=-0.041,P=0.002)。30~歲組、40~歲組、50~歲組、60~歲組、70~85歲組睪酮水平均低于20~歲組(P0.05)。6個年齡組睪酮水平年平均下降率為1.3%。30~歲組、40~歲組、50~歲組2011、2012、2013年睪酮水平均高于2014年(P0.05)。30~歲組睪酮水平年平均下降率為1.7%;40~歲組、50~歲組睪酮水平年平均下降率分別為1.5%、3.0%。各年齡組PADAM患病率比較,差異無統(tǒng)計學(xué)意義(P0.05)。50~歲組2011、2012、2013年P(guān)ADAM患病率均低于2014年(P0.05)。50~歲組PADAM患病率隨時間呈上升趨勢(P0.05)。Logistic回歸分析結(jié)果顯示,年份是PADAM患病率的影響因素(P0.05)。結(jié)論溫州地區(qū)健康男性睪酮水平隨年齡增長緩慢下降,30~59歲男性睪酮水平隨年齡升高逐步下降,50歲后睪酮水平相對平穩(wěn);50~59歲男性的PADAM患病率隨年份逐漸升高。
[Abstract]:Background as men age, decline of hypothalamus pituitary gonadal axis function, due to lack of testosterone in elderly men with partial androgen deficiency syndrome caused by (PADAM) will lead to abdominal obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, decline in skeletal muscle mass, sexual dysfunction, depression and cognitive disorders. Objective to investigate the prevalence rate of male testosterone levels and PADAM changes. Methods from 2011 to 2014 in the First Affiliated Hospital of Wenzhou Medical University examination with healthy male 5743 cases included in the standard as the research object. According to the age of 20~ years old group (142 cases), 30~ group (1261 cases), 40~ group (2346 cases) 50~, age group (1339 cases), 60~ group (552 cases), 70~85 group (103 cases). All subjects were detected and recorded. Testosterone levels in 20~ age group P10 testosterone levels (11.1 nmol/L) as the threshold value to determine the prevalence of PADAM. The results of study As the testosterone level was 15.14 (16.87,25.05) nmol/L, the average prevalence rate of PADAM was negatively correlated with 16.8%. levels of testosterone and age (rs=-0.041, P=0.002).30~ years old group, 40~ years group, 50~ years group, 60~ years group, 70~85 years group were lower than the testosterone levels in the age group of 20~ (P0.05).6 age group of testosterone the annual rate of decline in the 1.3%.30~ age group, 40~ group, 50~ group at the age of 201120122013 years testosterone levels were higher than that in 2014 (P0.05).30~ age group of testosterone level the average annual decline rate of 1.7%; 40~ years old group, 50~ years group decreased testosterone level year rates were 1.5%, 3.0%. years of age group compared the prevalence of PADAM, no statistically significant difference (P0.05).50~ age group of 201120122013 years the prevalence rate of PADAM was lower than that in 2014 (P0.05).50~ age group the prevalence rate of PADAM increased with time (P0.05) and.Logistic regression analysis showed that the year is the prevalence of PADAM impact factor (P0.05). Conclusion health in Wenzhou area The level of testosterone in male decreased slowly with age. The testosterone level decreased gradually with age. The testosterone level was relatively stable after 50 years of age. The prevalence of PADAM increased with age in 50~59 years old men.

【作者單位】： 溫州醫(yī)科大學(xué)附屬第一醫(yī)院醫(yī)學(xué)檢驗中心;
【基金】：溫州市科技局科技計劃項目(Y20140032)
【分類號】：R588.1
【正文快照】： Testosterone Level in Men and Prevalence of Partial Androgen Deficiency in the Aging Male CHEN Jian,PAN Qin-shi,WANG Yu-min,ZHOU Xing-xing.Center for Clinical Laboratory,the First Affiliated Hospital of Wenzhou MedicalUniversity,Wenzhou 325000,ChinaCorre

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