發(fā)布時(shí)間：2021-04-02 16:53

　　AIM:To develop a practical and reproducible rat model of hepatorenal syndrome for further study of the pathophysiology of human hepatorenal syndrome. METHODS:Sprague-Dawley rats were intravenously injected with D-galactosamine and lipopolysaccharide（LPS） via the tail vein to induce fulminant hepatic failure to develop a model of hepatorenal syndrome. Liver and kidney function tests and plasma cytokine levels were measured after D-galactosamine/LPS administration,and hepatic and renal pathology w... 

【文章來源】：World Journal of Gastroenterology. 2015,21(34)SCI

【文章頁數(shù)】：9 頁

【參考文獻(xiàn)】：
期刊論文
[1]Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure[J]. Li-Kun Wang,Lu-Wen Wang,Xun Li,Xiao-Qun Han,Zuo-Jiong Gong.  Hepatobiliary & Pancreatic Diseases International. 2013(02)
[2]Kidneys in chronic liver diseases[J]. Marek Hartleb,Krzysztof Gutkowski.  World Journal of Gastroenterology. 2012(24)
[3]Pentoxifylline improves liver regeneration through downregulation of TNF-α synthesis and TGF-β1 gene expression[J]. Rodrigo Bronze Martino,Ana Maria Mendona Coelho,Márcia Saldanha Kubrusly,Regina Leito,Sandra Nassa Sampietre,Marcel Cerqueira Cesar Machado,Telesforo Bacchella,Luiz Augusto Carneiro D’Albuquerque.  World Journal of Gastrointestinal Surgery. 2012(06)



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