【摘要】：目的探討血清降鈣素原(PCT)、可溶性細(xì)胞間黏附分子-1(sICAM-1)、可溶性血管細(xì)胞黏附分子-1(sVCAM-1)在慢性腎炎合并細(xì)菌感染中的應(yīng)用價(jià)值。方法選取2016年1-12月在醫(yī)院住院治療的慢性腎炎合并細(xì)菌感染為感染組與未合并細(xì)菌感染患者為無感染組,各50例,對感染部位分泌物進(jìn)行細(xì)菌培養(yǎng),檢測兩組血清sICAM-1、sVCAM-1,PCT。結(jié)果 50例患者共培養(yǎng)出病原菌58株,其中革蘭陰性菌34株占58.62%,革蘭陽性菌24株占41.38%,感染病原菌主要為肺炎克雷伯菌、大腸埃希菌、金黃色葡萄球菌;感染組入院時(shí)血清PCT、sICAM-1、sVCAM-1分別為(1.07±0.30)ng/ml、(336.97±56.92)ng/ml、(548.78±82.57)ng/ml,無感染組分別為(0.04±0.01)ng/ml、(246.81±63.05)ng/ml、(432.10±77.52)ng/ml,差異有統(tǒng)計(jì)學(xué)意義(P0.05);感染組感染控制后血清PCT、sICAM-1、sVCAM-1水平分別為(0.07±0.02)ng/ml、(260.12±60.11)ng/ml、(438.22±72.31)ng/ml低于感染控制前(1.07±0.30)ng/ml、(336.97±56.92)ng/ml、(548.78±82.57)ng/ml,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論慢性腎炎合并細(xì)菌感染后血清PCT、sICAM-1、sVCAM-1水平會出現(xiàn)升高,感染控制后以上指標(biāo)水平會隨之下降,檢測血清PCT、sICAM-1、sVCAM-1用于慢性腎炎合并細(xì)菌感染的診斷及治療療效觀察有一定臨床價(jià)值。
[Abstract]:Objective to investigate the value of serum procalcitonin (PCT), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in chronic nephritis complicated with bacterial infection. Methods from January to December 2016, 50 patients with chronic nephritis complicated with bacterial infection and 50 patients without bacterial infection were selected as infection group and 50 patients without bacterial infection in hospital from January to December 2016. The secretions from the infected sites were cultured and serum sICAM-1,sVCAM-1,PCT. was detected. Results A total of 58 strains of pathogenic bacteria were cultured from 50 patients, including 34 strains of Gram-negative bacteria (58.62%) and 24 strains of Gram-positive bacteria (41.38%). The main pathogenic bacteria were Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus. The serum PCT,sICAM-1,sVCAM-1 in the infection group was (1.07 鹵0.30) ng/ml, (336.97 鹵56.92) ng/ml, (548.78 鹵82.57) ng/ml, and (0.004 鹵0.001) ng/ml, (246.81 鹵63.05) ng/ml, (432.10 鹵77.52) ng/ml, in the non-infected group (P 0.05). The serum PCT,sICAM-1,sVCAM-1 levels in the infection group were (0.07 鹵0.002) ng/ml, (260.12 鹵60.11) ng/ml, (438.22 鹵72.31) ng/ml, respectively, which were significantly lower than those before infection control (1.07 鹵0.30) ng/ml, (336.97 鹵56.92) ng/ml, (548.78 鹵82.57) ng/ml, (P 0.05). Conclusion the level of serum PCT,sICAM-1,sVCAM-1 in patients with chronic nephritis complicated with bacterial infection will increase and the level of above indexes will decrease after infection control. The detection of serum PCT,sICAM-1,sVCAM-1 has certain clinical value in the diagnosis and treatment of chronic nephritis complicated with bacterial infection.
【作者單位】： 嘉興市第二醫(yī)院腎內(nèi)科;
【分類號】：R692.3
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本文編號：2514447