【摘要】：目的 :探討福建地區(qū)漢族2型糖尿病患者血清色素上皮衍生因子水平(pigment epithelium-derived factor,PEDF)及PEDF基因啟動子區(qū)rs1294385單核苷酸多態(tài)性與微量白蛋白尿的關(guān)系。方法 :471例2型糖尿病患者根據(jù)尿白蛋白/肌酐比值(urinary albumin to creatinine ratio,UACR)分為正常組(UACR30μg/mg,NAU組)246例、微量白蛋白尿組(30μg/mg≤UACR300μg/mg,MAU組)225例,使用PCR-RFLP方法檢測PEDF基因啟動子區(qū)rs1294385的多態(tài)性,同時檢測血清PEDF水平及空腹血糖、空腹胰島素、糖化血紅蛋白、血脂等指標。結(jié)果:MAU組的血清PEDF水平高于NAU組,差異有統(tǒng)計學意義(P0.05);偏相關(guān)分析顯示血清PEDF水平與UACR呈正相關(guān)(P0.05);PEDF基因啟動子區(qū)rs1294385的基因型(GG型、GA型和AA型)和等位基因(G/A)在NAU、MAU兩組間的分布存在差異,且差異有統(tǒng)計學意義(P0.05);GA基因型出現(xiàn)微量白蛋白尿的風險是GG基因型的1.838倍,GA+AA基因型出現(xiàn)微量白蛋白尿的風險是GG基因型的1.862倍,差異有統(tǒng)計學意義(P0.05)。結(jié)論:2型糖尿病患者血清PEDF水平隨微量白蛋白尿的出現(xiàn)而增高;福建地區(qū)漢族2型糖尿病患者PEDF基因啟動子區(qū)rs1294385多態(tài)性與微量白蛋白尿明顯相關(guān),攜帶A等位基因可能增加2型糖尿病患者發(fā)生微量白蛋白尿的機率。
[Abstract]:Objective: to investigate the relationship between microalbuminuria and serum pigment epithelium-derived factor (pigment epithelium-derived factor,PEDF) levels, rs1294385 single nucleotide polymorphisms in promoter region of PEDF gene and microalbuminuria in patients with type 2 diabetes mellitus in Fujian Han nationality. Methods: according to the urinary albumin / creatinine ratio (urinary albumin to creatinine ratio,UACR), 471 patients with type 2 diabetes were divided into two groups: normal group (UACR30 渭 g / mgnau group) and microalbuminuria group (30 渭 g/mg 鈮，

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