【摘要】：目的：通過補(bǔ)腎活血法聯(lián)合糖皮質(zhì)激素治療原發(fā)性腎病綜合征的臨床研究，初步評價補(bǔ)腎活血法聯(lián)合糖皮質(zhì)激素的中西醫(yī)結(jié)合治療方案在增強(qiáng)療效、減輕毒副反應(yīng)方面的作用。 方法：本研究收集原發(fā)性腎病綜合征符合中醫(yī)辨證腎虛血瘀證患者60例，分為試驗(yàn)組30例，對照組30例。對照組予免疫抑制、降蛋白尿等西醫(yī)基礎(chǔ)治療，試驗(yàn)組在西醫(yī)基礎(chǔ)治療上加用益腎活血湯，療程為3個月。觀察臨床癥狀、體征及實(shí)驗(yàn)室檢查指標(biāo)的變化，并對癥狀及體征進(jìn)行量化評分；觀察激素引起的副作用及減量過程中出現(xiàn)的反跳復(fù)發(fā)現(xiàn)象，，作出療效評價。 結(jié)果：試驗(yàn)組在改善臨床癥狀及檢驗(yàn)指標(biāo)方面均優(yōu)于對照組；試驗(yàn)組激素副作用的發(fā)生率總體上低于對照組。試驗(yàn)組能夠提高臨床緩解率，改善臨床癥狀；降低蛋白尿的排泄，升高血白蛋白水平，降低D二聚體，改善高凝狀態(tài)；減少激素的副作用及激素減藥過程中疾病的反跳和復(fù)發(fā)。 結(jié)論：補(bǔ)腎活血法結(jié)合糖皮質(zhì)激素治療原發(fā)性腎病綜合征具有提高激素療效、減輕激素毒副反應(yīng)的作用，中西醫(yī)聯(lián)合治療方案值得進(jìn)一步研究推廣應(yīng)用。
[Abstract]:Objective: to evaluate the effect of Bushen Huoxue method combined with glucocorticoid in the treatment of primary nephrotic syndrome. Methods: 60 patients with primary nephrotic syndrome were divided into experimental group (n = 30) and control group (n = 30). The control group was treated with basic western medicine such as immunosuppression and proteinuria. The experimental group was treated with Yishen Huoxue decoction for 3 months. The changes of clinical symptoms, physical signs and laboratory indicators were observed, and the scores of symptoms and signs were quantified, and the side effects caused by hormones and the phenomenon of rebound recurrence in the course of reduction were observed, and the curative effect was evaluated. Results: the experimental group was superior to the control group in improving clinical symptoms and testing indexes, and the incidence of hormone side effects in the trial group was lower than that in the control group. The experimental group can increase the clinical remission rate and improve the clinical symptoms, reduce the excretion of proteinuria, raise the level of serum albumin, reduce the D-dimer, improve the hypercoagulability, reduce the side effects of hormones, and reduce the rebound and recurrence of diseases in the course of hormone reduction. Conclusion: the therapy of tonifying kidney and activating blood circulation combined with glucocorticoid therapy can improve the effect of hormone and reduce the toxic and side effects of hormone. The combination of traditional Chinese and western medicine is worthy of further study and application.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R692

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 鄭夏珍;中藥對激素治療腎病綜合征的干預(yù)作用[J];安徽中醫(yī)臨床雜志;2003年06期

2 周碩果;;淺談腎病綜合征的中醫(yī)辨治[J];中醫(yī)藥臨床雜志;2005年06期

3 李笑春;戴敏;陳鵬;;丹皮酚對高脂血清誘導(dǎo)的大鼠主動脈內(nèi)皮細(xì)胞損傷的保護(hù)作用及其黏附功能的影響[J];安徽中醫(yī)學(xué)院學(xué)報;2010年01期

4 何永婷;朱賀年;;車前子的研究進(jìn)展[J];北方藥學(xué);2011年01期

5 付平,周莉,趙明生,李雪梅;燈盞細(xì)辛對原發(fā)性腎病綜合征高凝狀態(tài)和尿蛋白的影響[J];廣東醫(yī)學(xué);2003年10期

6 陳朝霞;;中西醫(yī)結(jié)合治療腎病綜合征36例療效觀察[J];甘肅中醫(yī);2006年11期

7 黃南龍;張碧玉;;簡述黃芪的藥理作用與臨床應(yīng)用[J];海峽藥學(xué);2009年01期

8 沈舒;王瓊;李友賓;;牛膝的化學(xué)成分和藥理作用研究進(jìn)展[J];海峽藥學(xué);2011年11期

9 孫中誠,董尚樸;腎病綜合征的中醫(yī)病因病機(jī)及辨證要點(diǎn)[J];河北中醫(yī);2003年03期

10 汪賢聰,郭志義,甘喜;中西醫(yī)結(jié)合治療成人原發(fā)性腎病綜合征42例[J];湖北中醫(yī)雜志;2001年04期

本文編號：2401760