【摘要】：目的：探索代謝綜合征及其組分對良性前列腺增生早期進展有無影響。方法：從我院體檢中心2012年3月至2012年7月進行健康體檢的899名中年男性中選取88例診斷為BPH的患者。按照聯(lián)合國世界衛(wèi)生組織確定的新的年齡分段，入組對象年齡限定為45-59歲。所有入組對象均詳細詢問健康史，并根據(jù)國際前列腺調(diào)查問卷詳細詢問患者有無下尿路癥狀及其嚴(yán)重程度，評出國際前列腺癥狀評分（International Prostatic Syndrome，IPSS）和生活質(zhì)量評分（Quality ofLife Score，QOL）。所有入組對象均測量身高、體重，并計算體重指數(shù)（Body Mass Index，BMI），測量血壓，經(jīng)腹彩超測前列腺體積（Prostate Volume，PV）。每位入組對象均采集清晨空腹血測空腹血糖、總膽固醇、甘油三酯、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇及血PSA。MS的診斷采用2004年中華醫(yī)學(xué)會糖尿病分會提出的診斷標(biāo)準(zhǔn)。根據(jù)不同的分組標(biāo)準(zhǔn)，分別對所有入組的88例入組對象進行分組，共有五種分類方法。根據(jù)是否合并MS，將所有入組對象分為BPH合并MS的實驗組和單純BPH的對照組，比較兩組間前列腺增生的指標(biāo)差異有無統(tǒng)計學(xué)意義。所有入組對象以BMI為分組標(biāo)準(zhǔn)，分為BMI正常組、超重組和肥胖組，比較三組間前列腺增生的指標(biāo)差異有無統(tǒng)計學(xué)意義。另外三種分類方法分別根據(jù)有無血脂、血壓或血糖異常，將所有入組對象分為TG正常組和高TG組，血壓正常組和血壓升高組，血糖正常組和高血糖組，分別比較各組前列腺增生的指標(biāo)差異有無統(tǒng)計學(xué)意義。應(yīng)用SPSS20.0軟件包對數(shù)據(jù)進行統(tǒng)計學(xué)分析，計量資料以x±s表示，計數(shù)資料用例數(shù)、百分比表示。計量資料的組間比較采用t檢驗，多組間比較采用單因素方差分析，計數(shù)資料及率的比較用χ2檢驗。 結(jié)果：1.BPH合并MS的實驗組與單純BPH的對照組相比，前列腺體積的差異具有統(tǒng)計學(xué)意義（p=0.048），PSA、IPSS、QOLS的差異無統(tǒng)計學(xué)意義； 2.超重和肥胖者與體重指數(shù)正常者相比，前列腺體積的差異有統(tǒng)計學(xué)意義（p=0.011），三組間PSA、IPSS、QOLS的差異無統(tǒng)計學(xué)意義； 3.高TG組與TG正常組比較，PV、IPSS、PSA、QOLS比較差異均無統(tǒng)計學(xué)意義； 4.血壓升高者與血壓正常者相比， IPSS的差異有統(tǒng)計學(xué)意義（p=0.006），而PV、PSA、QOLS的差異無統(tǒng)計學(xué)意義； 5.血糖升高患者與血糖正常者相比， PV的差異有統(tǒng)計學(xué)意義（p=0.009），而IPSS、PSA、QOLS的差異無統(tǒng)計學(xué)意義 結(jié)論：1.中年男性BPH患者中，MS對BPH的早期進展有促進作用。 2.中年男性BPH患者中，，MS組分中的超重、肥胖、空腹血糖升高及血壓升高對BPH的早期進展有促進作用。 3.中年男性BPH患者中，血脂異常對BPH無明顯影響。
[Abstract]:Objective: to explore the effect of metabolic syndrome and its components on the early progression of benign prostatic hyperplasia (BPH). Methods: 88 patients with BPH were selected from 899 middle-aged men who underwent physical examination in our hospital from March 2012 to July 2012. According to the new age segment established by the World Health Organization, the age limit for the group is 45-59 years. All participants were asked about their health history, and according to the International Prostate Survey questionnaire, the patients were asked whether they had lower urinary tract symptoms and their severity. The International Prostate symptom scale (International Prostatic Syndrome,IPSS) and the quality of Life score (Quality ofLife Score,) were evaluated. QOL). Height and weight were measured, body mass index (Body Mass Index,BMI) was calculated, blood pressure was measured and prostate volume (Prostate Volume,PV) was measured by transabdominal color Doppler ultrasound. Fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol were measured in each group. Low density lipoprotein cholesterol and serum PSA.MS were diagnosed according to the diagnostic criteria proposed by the Chinese Medical Association Diabetes Society in 2004. According to the different grouping criteria, 88 cases were grouped into groups, and there were five kinds of classification methods. According to the combination of MS, all the subjects were divided into two groups: the experimental group with BPH with MS and the control group with BPH alone. There was no statistical significance between the two groups in the index of prostatic hyperplasia. All the subjects were divided into normal BMI group, hyperrecombination group and obesity group according to BMI criteria. The other three classification methods were divided into TG normal group and high TG group, normal blood pressure group and elevated blood pressure group, normal blood glucose group and hyperglycemia group, according to whether there were abnormal blood lipids, blood pressure or blood sugar. The index difference of prostatic hyperplasia in each group was statistically significant. The data were analyzed by SPSS20.0 software package. The data were expressed as x 鹵s, and the counting data were expressed as the number of cases and the percentage. T test was used to compare measurement data, single factor analysis of variance (ANOVA) was used in multigroup comparison, 蠂 2 test was used to compare counting data and rate. Results: there was significant difference in prostate volume between the experimental group of 1.BPH and MS and the control group of BPH alone (p0. 048), but the difference of PSA,IPSS,QOLS was not statistically significant. 2. There was significant difference in prostate volume between overweight and obese patients and normal BMI group (p0. 011), but there was no significant difference in PSA,IPSS,QOLS among the three groups. 3. There was no significant difference in PV,IPSS,PSA,QOLS between high TG group and normal TG group. 4. The difference of IPSS between patients with elevated blood pressure and normal blood pressure was statistically significant (p0. 006), but the difference of PV,PSA,QOLS was not statistically significant. The difference of PV between patients with hyperglycemia and those with normal blood glucose was statistically significant (p0. 009), but the difference of IPSS,PSA,QOLS was not statistically significant: 1. In middle-aged male patients with BPH, MS promotes the early progression of BPH. 2. In middle-aged male patients with BPH, overweight, obesity, elevated fasting blood glucose and elevated blood pressure in the MS component contributed to the early progression of BPH. 3. In middle-aged male patients with BPH, dyslipidemia had no significant effect on BPH.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R589;R697.3

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