【摘要】：目的觀察4 043例男性不育患者的Y染色體多態(tài)性。方法 4 043例已婚男性不育患者(年齡24~45歲,平均31.5歲)的外周血2.5 m L進(jìn)行體外血細(xì)胞培養(yǎng),G顯帶外周血染色體核型分析Y染色體多態(tài)性。結(jié)果4 043例中共有119例(2.94%)患者檢出多態(tài)Y染色體,其中大Y(Y長度≥18號染色體)、小Y(Y≤21號染色體〉、Y染色體臂間倒位[inv(Y)]分別為88(2.18%)、25(0.62%)、6(0.15%)例。基因表現(xiàn)為46,XY(大Y)的男性患者中臨床表現(xiàn)為流產(chǎn)35例、少弱精及無精癥30例、不育23例;基因表現(xiàn)為46,XY(小Y)的男性患者中臨床表現(xiàn)為少弱精及無精癥12例、不育11例、流產(chǎn)3例;基因表現(xiàn)為46,X,inv(Y)的男性患者中臨床表現(xiàn)為流產(chǎn)3例、少弱精及無精癥2例、不育1例。結(jié)論 24~45歲已婚男性不育患者Y染色體多態(tài)比例較高。存在Y染色體多態(tài)的24~45歲已婚男性不育患者主要臨床表現(xiàn)為流產(chǎn)、少弱精及無精、不育等。
[Abstract]:Objective to observe Y chromosome polymorphism in 4 043 infertile men. Methods 4 043 married male infertile patients (aged 24 to 45 years, mean 31.5 years) were cultured in vitro with 2.5 mL peripheral blood cells. The chromosome karyotype of G banded peripheral blood was analyzed for Y chromosome polymorphism. Results polymorphic Y chromosomes were detected in 119 of 4 043 patients (2.94%), in which large Y (Y length 鈮，

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