發(fā)布時(shí)間：2018-11-05 18:22

【摘要】：目的獲取中國(guó)成人及老年人慢性腎臟病(CKD)患病率。方法檢索Pub Med、Sino Med、CNKI、維普、萬(wàn)方2007~2017年有關(guān)中國(guó)成人CKD流行病學(xué)調(diào)查研究對(duì)性別、老年、蛋白尿、血尿、腎小球?yàn)V過(guò)率(e GFR)下降(60 ml/min)及地理分區(qū)進(jìn)行亞組分析,并與中國(guó)大型橫斷面研究比較。結(jié)果最終納入文獻(xiàn)28篇,總調(diào)查161 084例,Egger回歸顯示不存在發(fā)表偏倚(P0.05)。中國(guó)成人CKD未標(biāo)化患病率為13.39%,女性患病率為14.41%,男性10.17%,60歲及以上老年人群患病率19.25%,60歲以下人群8.71%;蛋白尿、血尿及e GFR下降未標(biāo)化患病率分別為7.30%、5.79%和2.59%;與中國(guó)大型橫斷面研究結(jié)果一致。西南地區(qū)CKD患病率最高為15.08%,華南地區(qū)最低(10.33%)。結(jié)論中國(guó)成人CKD患病率較高,老年人群尤為顯著,單組率Meta分析結(jié)果可靠,加強(qiáng)CKD早期診斷及有效干預(yù)十分必要。
[Abstract]:Objective to investigate the prevalence of chronic kidney disease (CKD) in Chinese adults and the elderly. Methods Pub Med,Sino Med,CNKI, Viper, Wanfang 2007- 2017 Chinese adult CKD epidemiological study on gender, elderly, proteinuria, hematuria, Glomerular filtration rate (e GFR) decreased (60 ml/min) and geographic subgroup analysis was performed, and compared with large cross-sectional study in China. Results 28 articles were included and 161,084 cases were investigated. Egger regression showed that there was no publication bias (P0.05). The unstandardized prevalence rate of CKD in Chinese adults was 13.39, the prevalence rate of female was 14.41, and the prevalence rate of male 10.17 was 19.25% and below 60 years old. The unstandardized prevalence of proteinuria, hematuria and e GFR decrease was 7.3079% and 2.59%, respectively, which was consistent with the results of large cross-sectional studies in China. The prevalence rate of CKD was the highest in southwest China (15.08%) and the lowest in South China (10.33%). Conclusion the prevalence of CKD in Chinese adults is high, especially in the elderly. The results of single group Meta analysis are reliable. It is necessary to strengthen the early diagnosis and effective intervention of CKD.
【作者單位】： 海南醫(yī)學(xué)院第一附屬醫(yī)院腎內(nèi)科;海南醫(yī)學(xué)院第一附屬醫(yī)院血透科;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(No.81660131)
【分類號(hào)】：R692

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