發(fā)布時間：2018-10-25 13:41

【摘要】：目的探討X線修復交叉互補(XRCC1)基因rs25487位點多態(tài)性在陜西回族非梗阻性無精癥人群中的分布及其與非梗阻性無精癥發(fā)病風險的關(guān)聯(lián)。方法采用聚合酶鏈反應-限制性片段長度多態(tài)性(PCR-RFLP)。方法檢測79例陜西回族非梗阻性無精癥患者和82例陜西回族正常對照男性人群XRCC1基因rs25487位點的基因分型和等位基因頻率,分析其與非梗阻性無精癥發(fā)病的相關(guān)性。結(jié)果與GG基因型的個體相比,攜帶GA基因型的個體患非梗阻性無精癥的風險是攜帶GG基因型個體的2.286倍;攜帶AA基因型的個體患非梗阻性無精癥的風險是GG基因型個體的2.202倍;攜帶GA+AA基因型的個體患非梗阻性無精癥的風險是GG基因型的2.271倍。與G等位基因相比,攜帶A等位基因的個體患非梗阻性無精癥的風險是G基因的1.158倍。結(jié)論 XRCC1基因rs25487位點G→A與陜西回族人群非梗阻性無精癥發(fā)病風險存在關(guān)聯(lián)。
[Abstract]:Objective to investigate the distribution of rs25487 locus polymorphism of X-ray repair crossover complement (XRCC1) gene in Shaanxi Hui non-obstructive azoospermia and its association with the risk of non-obstructive azoospermia. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used. Methods the genotyping and allelic frequency of XRCC1 gene rs25487 locus were detected in 79 non-obstructive azoospermia patients in Shaanxi Hui nationality and 82 healthy controls in Shaanxi Hui nationality, and the correlation between rs25487 locus and the incidence of non-obstructive azoospermia was analyzed. Results compared with individuals with GG genotype, individuals with GA genotype were 2.286 times more likely to suffer from non-obstructive azoospermia than those with GG genotype, individuals with AA genotype were 2.202 times more likely to develop non-obstructive azoospermia than those with GG genotype. Individuals with GA AA genotypes were 2.271 times more likely to develop non-obstructive azoospermia than those with GG genotypes. Individuals with A allele were 1.158 times more likely to develop non-obstructive azoospermia than those with G allele. Conclusion there is an association between the rs25487 locus of XRCC1 gene and the risk of non-obstructive azoospermia in Shaanxi Hui population.
【作者單位】： 西安交通大學醫(yī)學部病理系;西北婦女兒童醫(yī)院生殖中心;西安交通大學第二附屬醫(yī)院泌尿外科;
【基金】：國家自然科學基金資助項目(No.81273018,30700654) 陜西省自然科學基金資助(No.2015JM8436) 陜西省衛(wèi)生廳基金(No.2012D58) 中央高�；究蒲袠I(yè)務費(No.XJJ2011024)~~
【分類號】：R698.2

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