老年血液透析患者血清甲狀旁腺激素水平及影響因素分析
發(fā)布時(shí)間:2018-07-22 13:38
【摘要】:目的:分析老年血液透析患者的甲狀旁腺激素水平的異常情況及其影響因素。 方法:選取重慶市醫(yī)科大學(xué)附屬第二醫(yī)院血液凈化中心2013年12月份規(guī)律血液透析治療3個(gè)月以上的病情穩(wěn)定的患者,排除近期發(fā)生感染、嚴(yán)重心腦血管事件、出血、骨折、肝病、自身免疫性疾病、甲狀旁腺切除術(shù)后、未達(dá)干體重標(biāo)準(zhǔn)患者。檢測患者透前血紅蛋白(Hb)、高敏C反應(yīng)蛋白(Hs-CRP)、血鈣(Ca)、血磷(P)、血清白蛋白(ALB)、甘油三酯(TG)、低密度脂蛋白(LDL)、全段甲狀旁腺激素(iPTH),同一次透析前后血尿素氮(BUN)、血肌酐(Scr),計(jì)算Kt/V值。根據(jù)患者年齡分為老年組(≥65歲)和中青年組(65歲)。 結(jié)果: 1.符合觀察標(biāo)準(zhǔn)的血透患者有116人,男性67人,女性49人,老年組占43人(37.1%),中青年組占73人(63.9%),平均年齡59.5±16.9(20~89)歲,平均透析齡為36.1±26.8(3~143)月。終末期腎臟疾病的病因?yàn)樘悄虿∧I病43例,慢性腎小球腎炎33例,高血壓腎病27例,多囊腎8例,其他腎臟疾病5例。 2. iPTH 60pg/ml的血透患者占19人(16.4%),60pg/ml≤iPTH150pg/ml的血透患者占27人(23.3%),150pg/ml≤iPTH≤300pg/ml血透患者占34人(29.3%),300pg/ml iPTH≤600pg/ml的血透患者占21人(18.1%), iPTH600pg/ml的血透患者占15人(12.9%)。 3.老年組的主要病因?yàn)樘悄虿∧I病,中青年組主要病因?yàn)槁阅I小球腎炎。老年組與中青年組比較,干體重質(zhì)量低,使用VitD的人數(shù)較少,均具有統(tǒng)計(jì)學(xué)意義,P 0.05。老年組與中青年組的性別比例、BMI、平均動(dòng)脈壓、透析時(shí)間、Kt/V值在統(tǒng)計(jì)學(xué)上無顯著差別,, P0.05。 4.老年組的Ca、Hs-CRP水平較較中青年組高,iPTH、BUN、Cre、TG水平較中青年組低,以上均具有統(tǒng)計(jì)學(xué)意義,P 0.05。 5.老年組中iPTH水平與BMI、P、BUN、Cre、Hb、ALB呈正相關(guān),與Ca呈負(fù)相關(guān),與年齡、透析齡、Kt/V值、Hs-CRP、TG、LDL無相關(guān)性。中青年組中iPTH水平與透析齡、Cre呈正相關(guān),與年齡呈負(fù)相關(guān),與Kt/V值、干體重、HGB、Ca、P、Hs-CRP、ALB、TG、LDL無相關(guān)性。 結(jié)論: 1.老年血透患者以糖尿病腎病為主,營養(yǎng)狀況較差,微炎癥反應(yīng)重,血清甲狀旁腺激素水平明顯偏低。 2.老年血透患者的血清甲狀旁腺激素水平受營養(yǎng)狀況的影響,而中青年血透患者隨著透析齡的延長血清甲狀旁腺激素水平明顯升高。
[Abstract]:Objective: to analyze the abnormal level of parathyroid hormone in elderly hemodialysis patients and its influencing factors. Methods: regular hemodialysis was performed in the blood purification center of the second affiliated Hospital of Chongqing Medical University in December 2013 to treat the patients with stable condition for more than 3 months. The patients were excluded from recent infection, severe cardiovascular and cerebrovascular events, hemorrhage and fracture. Liver disease, autoimmune disease, after parathyroidectomy, not up to dry weight standard patients. The levels of predialysis hemoglobin (HB), Gao Min C-reactive protein (Hs-CRP), serum calcium (Ca), serum phosphorus (P), serum albumin (ALB), triglyceride (TG), low density lipoprotein (LDL), total parathyroid hormone (iPTH), blood urea nitrogen (bun), serum creatinine (SCR) before and after the same dialysis were measured. According to the age of the patients, they were divided into the old group (鈮
本文編號(hào):2137638
[Abstract]:Objective: to analyze the abnormal level of parathyroid hormone in elderly hemodialysis patients and its influencing factors. Methods: regular hemodialysis was performed in the blood purification center of the second affiliated Hospital of Chongqing Medical University in December 2013 to treat the patients with stable condition for more than 3 months. The patients were excluded from recent infection, severe cardiovascular and cerebrovascular events, hemorrhage and fracture. Liver disease, autoimmune disease, after parathyroidectomy, not up to dry weight standard patients. The levels of predialysis hemoglobin (HB), Gao Min C-reactive protein (Hs-CRP), serum calcium (Ca), serum phosphorus (P), serum albumin (ALB), triglyceride (TG), low density lipoprotein (LDL), total parathyroid hormone (iPTH), blood urea nitrogen (bun), serum creatinine (SCR) before and after the same dialysis were measured. According to the age of the patients, they were divided into the old group (鈮
本文編號(hào):2137638
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