【摘要】：目的通過(guò)檢測(cè)反映腎功能的生化代謝指標(biāo),在常規(guī)體檢人群中探討腎功能指標(biāo)異常的分子水平"亞健康"狀態(tài)。方法 2013年1月-2014年8月在石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院參加健康體檢的13 100漢族個(gè)體接受了空腹常規(guī)血液檢測(cè)尿酸、尿素氮、肌酐和胱抑素C 4項(xiàng)指標(biāo),體檢者無(wú)癥狀主訴。結(jié)果尿酸、尿素氮、胱抑素C和肌酐異常升高率分別為14.05%、1.90%、0.82%和0.33%。在尿酸、尿素氮、胱抑素C和肌酐水平異常的體檢者中,80%集中在21~50歲青壯年。男性尿酸、尿素氮、胱抑素C及肌酐水平與女性比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。男性:尿酸(353.51±80.44)μmol/L,尿素氮(5.21±1.34)mmol/L,胱抑素C(0.87±0.24)mg/L,肌酐(78.59±13.83)μmol/L;女性:尿酸(245.65±62.24)μmol/L,尿素氮(4.50±1.26)mmol/L,胱抑素C(0.74±0.23)mg/L,肌酐(58.83±10.08)μmol/L。尿素氮、胱抑素C及肌酐水平與年齡呈正相關(guān),但尿酸水平與年齡無(wú)相關(guān)。結(jié)論首次在新疆地區(qū)對(duì)漢族體檢人群進(jìn)行大樣本調(diào)查,在無(wú)相關(guān)臨床癥狀體檢者中發(fā)現(xiàn)4種腎功能相關(guān)代謝物血液水平異常升高,藉此首次提出"分子水平亞健康"的概念。這種"分子水平亞健康"可能是腎臟相關(guān)疾病的早期預(yù)警信號(hào),應(yīng)該受到預(yù)防公共衛(wèi)生的高度關(guān)注。
[Abstract]:Objective to investigate the biochemical metabolic indices reflecting renal function and to explore the molecular level "subhealth" state of abnormal renal function index in the routine physical examination population. Methods 13100 Han bodies who participated in healthy physical examination in the First Affiliated Hospital of Shihezi University Medical College in August -2014 were accepted the routine blood test of urate and urea in the First Affiliated Hospital of Shihezi University Medical College in January 2013. The 4 indexes of nitrogen, creatinine and cystatin C were asymptomatic complaints. Results the abnormal elevated rates of uric acid, urea nitrogen, Cystatin C and creatinine were 14.05%, 1.90%, 0.82% and 0.33%. in patients with abnormal levels of uric acid, urea nitrogen, Cystatin C and creatinine. 80% were in the young and middle-aged 21~50 years old. The level of uric acid, urea nitrogen, Cystatin C and creatinine levels in men. Compared with women, the difference was statistically significant (P0.05): uric acid (353.51 + 80.44) mu mol/L, urea nitrogen (5.21 + 1.34) mmol/L, Cystatin C (0.87 + 0.24) mg/L, creatinine (78.59 + 13.83) mu mol/L, female: uric acid (245.65 + 62.24) mu mol/L, urea nitrogen (4.50 + 1.26) mmol/L, Cystatin C (0.74 +) mg/L, creatinine mol/L. urea nitrogen, cystine, cysteine The level of serum C and creatinine was positively correlated with age, but the level of uric acid was not related to age. Conclusion a large sample survey was conducted for the first time in the Han population in Xinjiang, and the abnormal elevated blood levels of 4 kinds of renal function related metabolites were found in those who had no related clinical symptoms. This was the first time to propose the concept of "molecular level subhealth". The "molecular level sub-health" may be an early warning signal for kidney related diseases and should be highly concerned with public health.
【作者單位】： 石河子大學(xué)醫(yī)學(xué)院病理系;石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院檢驗(yàn)科;石河子大學(xué)醫(yī)學(xué)院預(yù)防醫(yī)學(xué)系;
【分類號(hào)】：R692

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