本文選題：前列腺癌 + 硫磺��； 參考：《復(fù)旦大學(xué)》2014年碩士論文

【摘要】：前列腺癌是全球第六大癌癥,也是全球男性第二大癌癥。歐美國家前列腺癌發(fā)病率高于亞洲國家,發(fā)病率在100/10萬,是最常見的男性泌尿生殖系統(tǒng)惡性腫瘤之一。而近年來,隨著人壽命的延長以及飲食結(jié)構(gòu)的改變,我國前列腺癌的發(fā)病率穩(wěn)步升高,從2002年的1.6/10萬到2012年的9.92/10萬,增加了5倍。早期前列腺癌細胞生長依賴于雄激素,通過雄激素剝奪法能夠有效治療,而當其進入雄激素抵抗階段后由于缺乏有效治療手段,患者的生活和生命都受到很多威脅。因此,尋找用于治療晚期雄激素非依賴性前列腺癌的藥物及手段,成為大家關(guān)注的熱點。常用的研究雄激素非依賴性前列腺癌細胞系有DU-145,PC-3,22Rv1等,DU-145和PC-3不表達雄激素受體AR,也不分泌PSA;22Rv1的生長不受雄激素調(diào)控,但是其能夠表達低水平的AR,并分泌少量PSA,生長依然依賴于AR信號通路,這與臨床復(fù)發(fā)性前列腺癌特點一致。硫磺作為藥物的入藥成分廣泛用于各類疾病的治療中。近年來,中藥被用于前列腺癌的治療中,尤其對于晚期雄激素抵抗階段的前列腺癌,中醫(yī)治療己成為主要的手段。硫磺為中藥的入藥成分中的一種,曾有報道指出硫磺具有一定的抑癌作用,因此研究硫磺對前列腺癌的抑制作用具有重要意義。MEIN是由乳清蛋白多肽和乳酸桿菌發(fā)酵產(chǎn)物組成。其主要成分乳清蛋白多肽作為一種營養(yǎng)補充劑,具有低膽固醇、脂肪和乳糖含量,易消化吸收,具有極高的生物利用價值。已有的病例報道指出,乳清蛋白粉對泌尿生殖系統(tǒng)癌癥患者的術(shù)后恢復(fù)、提高患者的生活水平具有重要作用。本文分兩個獨立部分,分別探究硫磺和MEIN對雄激素非依賴性前列腺腫瘤生長的影響及其可能機制。
[Abstract]:Prostate cancer is the sixth largest cancer in the world and the second largest in men. The incidence of prostate cancer in Europe and America is higher than that in Asia, with an incidence of 100 to 100, 000, making it one of the most common malignant tumors in the male genitourinary system. In recent years, with the prolongation of life expectancy and the change of dietary structure, the incidence of prostate cancer in China has increased steadily, from 1.6 / 100000 in 2002 to 99.2 / 100000 in 2012, which has increased fivefold. Early prostate cancer cells are dependent on androgen and can be effectively treated by androgen deprivation. However, when they enter androgen resistance stage, their lives and lives are threatened because of the lack of effective treatment. Therefore, searching for drugs and methods for the treatment of advanced androgen-independent prostate cancer has become a hot topic. The commonly used androgen independent prostate cancer cell lines DU-145, PC-3O22Rv1 and so on do not express androgen receptor AR-1, nor do they secrete PSA-22Rv1, which are not regulated by androgen. However, it can express low levels of ARs and secrete a small amount of PSA.The growth is still dependent on AR signaling pathway, which is consistent with the clinical characteristics of recurrent prostate cancer. Sulfur is widely used in the treatment of various diseases. In recent years, traditional Chinese medicine has been used in the treatment of prostate cancer, especially for advanced androgen resistance stage prostate cancer, Chinese medicine treatment has become the main means. Sulfur is one of the traditional Chinese medicine ingredients, it has been reported that sulfur has a certain anti-cancer effect, so it is important to study the inhibitory effect of sulfur on prostate cancer. MEIN is composed of whey protein polypeptide and Lactobacillus fermentation product. As a nutritional supplement, whey protein polypeptide has low cholesterol, fat and lactose content, easy to digest and absorb, and has high bioavailability. It has been reported that whey protein powder plays an important role in postoperative recovery and improvement of living standards of patients with urogenital cancer. This paper is divided into two independent parts to explore the effect of sulfur and MEIN on androgen independent prostate tumor growth and its possible mechanism.
【學(xué)位授予單位】：復(fù)旦大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R737.25

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本文編號：2095488