本文選題：AKI + IGFBP7��； 參考：《石河子大學(xué)》2017年碩士論文

【摘要】：目的:探討尿胰島素樣生長因子結(jié)合蛋白7(IGFBP7)在急性腎損傷(AKI)診斷中的價值和意義,為AKI的及時診斷、腎功能評估提供可靠依據(jù)。方法:選擇2015年12月-2016年5月新疆石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院住院及門診患者為研究對象。嚴(yán)格按照納入標(biāo)準(zhǔn)及排除標(biāo)準(zhǔn),共入組AKI患者50例,慢性腎臟病(chronic kidney diseases,CKD)患者30例,與之性別、年齡、體重相匹配的健康體檢者30例。收集入組患者的基礎(chǔ)資料(性別、年齡等),所有入選者均于確診后留取24h內(nèi)第1次晨尿(中段尿)及晨起空腹血標(biāo)本,生化分析儀檢測血胱抑素C(serum Cystatin C,s Cys C)、血肌酐(Serum creatinine,Scr)水平(膠乳增強免疫透射比濁法檢測s Cys C;酶法檢測Scr),采用酶聯(lián)免疫吸附法(enzyme-linked immunosorbent assay,ELISA)檢測尿IGFBP7的水平,整理三組所有研究資料統(tǒng)計學(xué)綜合分析。結(jié)果:1.與正常組、CKD組相比,AKI組的尿IGFBP7水平顯著升高,差異有統(tǒng)計學(xué)意義(P0.05);與正常組相比,AKI組s Cys C水平明顯升高,差異有統(tǒng)計學(xué)意義(P0.05);與CKD組相比,AKI組s Cys C水平較CKD組稍升高,差異無統(tǒng)計學(xué)意義(P0.05);隨AKI各期進展尿IGFBP7、血清s Cys C水平逐漸升高,各期之間差異具有統(tǒng)計學(xué)意義(P0.05)。2.直線相關(guān)分析顯示:AKI組中尿IGFBP7與s Cys C及Scr呈正相關(guān)(r=0.782,P0.01;r=0.884,P0.01)。3.ROC曲線分析顯示:在AKI診斷中,尿IGFBP7曲線下面積為0.889(95%CI 0.813~0.966,P0.01);s Cys C曲線下面積為0.877(95%CI 0.803~0.951;P0.01)。結(jié)論:1.尿IGFBP7在AKI患者中顯著升高,且在診斷AKI方面有著較好的準(zhǔn)確度和敏感性,故有望成為診斷AKI的新生物學(xué)標(biāo)記物。2.尿IGFBP7隨AKI各期進展逐漸升高,對AKI的分期有重要指導(dǎo)意義。
[Abstract]:Objective: to investigate the value and significance of urinary insulin-like growth factor binding protein 7 (IGFBP7) in the diagnosis of acute renal injury (AKI), and to provide reliable basis for the timely diagnosis of AKI and the evaluation of renal function. Methods: the inpatients and outpatients in the first affiliated Hospital of Medical College of Shihezi University of Xinjiang were selected from December 2015 to May 2016. According to the inclusion criteria and exclusion criteria, 50 patients with AKI, 30 patients with chronic kidney disease (chronic kidney disease), 30 healthy persons matched with sex, age and body weight were enrolled. The basic data (sex, age, etc.) of the patients were collected. The first morning urine (middle urine) and fasting blood samples were collected in 24 hours after diagnosis. Serum cystatin C (serum Cystatin C), serum creatinine (creatinine SCR) (latex enhanced transmission turbidimetric assay (RIA) and enzyme assay (SCR) were detected by biochemical analyzer, and the levels of urinary IGFBP7 were detected by enzyme-linked immunosorbent assay-linked immunosorbent assay (Elisa). All the data of three groups were analyzed statistically. The result is 1: 1. The level of urinary IGFBP7 in AK AKI group was significantly higher than that in normal control group (P0.05), the level of sCys C in AKI group was significantly higher than that in normal group (P0.05), the level of sCys C in AKI group was slightly higher than that in CKD group (P0.05), the level of sCys C in AKI group was slightly higher than that in CKD group (P0.05), the level of sCys C in AKI group was significantly higher than that in control group (P0.05). There was no significant difference (P0.05); with the progress of AKI, the level of serum sCys C gradually increased with the progression of AKI (P0.05). 2. Linear correlation analysis showed that there was a positive correlation between urinary IGFBP7 and sCys C and SCR (rn 0.782n P0.01P 0.01P 0.884P 0.01). 3. The area under the curve of urine IGFBP7 was 0.889 (95 CI 0.8130.966P0.01) in AKI group, and the area under the curve was 0.877 (95CI 0.8030.951 P0.01). Conclusion 1. Urinary IGFBP7 is significantly increased in AKI patients, and has good accuracy and sensitivity in the diagnosis of AKI, so it may become a new biological marker of AKI diagnosis. Urinary IGFBP7 increases gradually with the development of AKI, which is of great significance to the staging of AKI.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R692.5

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