本文選題：IgA腎病 + 性別��； 參考：《西安交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年02期

【摘要】：目的探討不同性別原發(fā)性IgA腎病患者的臨床病理特點(diǎn)。方法對(duì)經(jīng)腎臟活檢確診的192例IgA腎病患者不同性別的臨床表現(xiàn)、實(shí)驗(yàn)室檢查及腎臟病理進(jìn)行對(duì)比分析。結(jié)果男性患者發(fā)病年齡高于女性,腎活檢前病程長于女性,水腫的比例低于女性,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。腎臟穿刺時(shí),男性平均動(dòng)脈壓、血紅蛋白、24h尿蛋白定量高于女性,男性高血壓、高尿酸血癥、高甘油三酯血癥比例高于女性;而男性腎小球?yàn)V過率(eGFR)低于女性,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。臨床病理類型的性別分布差異有統(tǒng)計(jì)學(xué)意義(χ~2=12.666,P0.05),均以U-ab型、MP型為主;24h尿蛋白、CKD分組的性別分布差異有統(tǒng)計(jì)學(xué)意義(Z=-3.118、Z=-3.246,P0.05)。病理Lee分級(jí)、免疫熒光類型無性別分布差異(Z=-1.881,χ~2=-0.187,P0.05);腎小管-間質(zhì)病變分級(jí)(TIL分級(jí))的性別分布差異有統(tǒng)計(jì)學(xué)意義(Z=-3.0432,P0.05);腎小球硬化評(píng)分、腎小管間質(zhì)評(píng)分兩指標(biāo)均為男性高于女性(P0.05)。結(jié)論原發(fā)性IgA腎病患者臨床和病理改變存在一定性別差異,男性患者臨床病理改變較女性嚴(yán)重。
[Abstract]:Methods 192 patients with IgA nephropathy diagnosed by renal biopsy were compared with each other in clinical manifestation, laboratory examination and renal pathology. Results the onset age of male patients was higher than that of females, the course of disease before renal biopsy was longer than that of females, and the proportion of edema was lower than that of females, and the difference was statistically significant (P 0.05). During renal puncture, the mean arterial pressure and 24-hour urinary protein quantification of hemoglobin in males were higher than those in females. The proportion of hypertension, hyperuricemia and hypertriglyceridemia in males was higher than that in females, while the glomerular filtration rate (GFR) in males was lower than that in females. The difference was statistically significant (P 0.05). The sex distribution of clinicopathological types was significantly different (蠂 ~ (2 / 2) ~ (12.666) P0.05, and the sex distribution of urinary proteinuria CKD was significantly different in 24 hours urinary protein group with U-ab type (P < 0.05). There was a significant difference in the sex distribution of CKD between two groups (Z ~ (-3.118) ~ (-3.246) ~ (-3.246) (P ~ (0.05). There was no difference in the sex distribution of immunofluorescence type between two groups. There was no significant difference in sex distribution between the two groups. There were significant differences in sex distribution between male and female patients with renal tubulointerstitial lesion grade and tubulointerstitial lesion grade, and the glomerulosclerosis score and tubulointerstitial score were both higher in male than in female. Conclusion the clinical and pathological changes of patients with primary IgA nephropathy are different in sex, and the clinicopathological changes of male patients are more serious than that of women.
【作者單位】： 西安交通大學(xué)醫(yī)院;西安交通大學(xué)第一附屬醫(yī)院腎病中心;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(No.81200528)~~
【分類號(hào)】：R692.31

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