本文選題：腎病 + 蛋白尿　； 參考：《中國全科醫(yī)學(xué)》2017年S2期

【摘要】：目的探討蛋白尿與Lee氏分級(jí)與免疫球蛋白A腎病(IgAN)患者腎損傷程度的相關(guān)性分析。方法選取深圳市第二人民醫(yī)院2010年12月—2016年10月登記的IgAN患者507例,根據(jù)Lee氏分級(jí)分為低級(jí)別病理組(n=163)和高級(jí)別病理組(n=344)。比較兩組患者清蛋白(Alb)、24 h蛋白尿定量、血肌酐(Scr)、血尿酸(UA)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)及低密度脂蛋白膽固醇(LDL-C),并分析蛋白尿與Lee氏分級(jí)的相關(guān)性及其與免疫球蛋白A腎病患者腎損傷程度影響因素分析。結(jié)果高級(jí)別病理組患者Alb、24 h蛋白尿定量、Scr、UA、TC、TG、LDL-C高于低級(jí)別病理組,HDL-C低于低級(jí)別病理組(P0.05)。IgA腎病腎損傷程度多因素logistic回歸分析結(jié)果顯示,Lee氏分級(jí)、24 h蛋白尿定量是影響IgA腎病腎損傷程度的獨(dú)立危險(xiǎn)因素(P0.05)。腎臟病理Lee氏分級(jí)與24 h尿蛋白定量成正相關(guān)(P0.05)。結(jié)論蛋白尿與Lee氏分級(jí)呈正相關(guān),且Lee氏分級(jí)、24 h蛋白尿定量是影響IgA腎病腎損傷程度的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to investigate the correlation between proteinuria and Lee's grade and IgANs in patients with immunoglobulin A nephropathy. Methods 507 IgAN patients registered in Shenzhen second people's Hospital from December 2010 to October 2016 were divided into low grade pathological group (n = 163) and high grade pathology group (n = 3444) according to Lee's grade. 24 h proteinuria was compared between the two groups. Serum creatinine (SCR), serum uric acid (UAA), total cholesterol (TC), triglyceride (TGG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were analyzed. The correlation between proteinuria and Lee's grade and renal injury in patients with immunoglobulin A nephropathy were analyzed. Analysis of influencing factors of degree. Results the results of logistic regression analysis showed that 24 h proteinuria in high grade pathological group was significantly lower than that in low grade pathological group (P 0.05). The results of multivariate logistic regression analysis showed that the 24 h proteinuria quantitative analysis of Lee's grade and 24 h proteinuria was related to IgA. The independent risk factor of renal injury was P0.05. There was a positive correlation between Lee's grade of renal pathology and 24 h urinary protein quantification (P0.05). Conclusion there is a positive correlation between proteinuria and Lee's grade, and the quantitative analysis of proteinuria in 24 hours is an independent risk factor for renal injury of IgA nephropathy.
【作者單位】： 廣東省深圳市第二人民醫(yī)院腎內(nèi)科;
【分類號(hào)】：R692.31
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本文編號(hào)：1999370