本文選題：前列腺癌 + 前列腺癌根治術(shù)　； 參考：《浙江大學(xué)》2015年碩士論文

【摘要】：目的： 前列腺腺癌是老年男性常見(jiàn)的惡性腫瘤,50以下男性前列腺腺癌也在逐年增加。探討年齡50歲前列腺腺癌患者的臨床特征。 方法： 回顧性分析2008年1月至2014年3月收治的21例前列腺腺癌患者的臨床資料。確診時(shí)年齡42～49歲,中位值48歲。tPSA10μg/L17例,4～10μg/L4例。21例均經(jīng)病理確診。Gleason評(píng)分6分3例,7分6例(3+4分5例,4+3分1例),8分7例,9分5例。臨床分期T2N0M0期16例,T3NoMo期1例,T4NxM0期1例,T3-4N1M1期3例。16例(T2N0M0期15例,T3N0Mo期1例)行根治性前列腺切除術(shù),5例行藥物去勢(shì)治療。 結(jié)果： 行根治性前列腺切除術(shù)16例中,隨訪3-65個(gè)月,中位值23個(gè)月,14例無(wú)生化復(fù)發(fā),1例因包膜侵犯術(shù)后1個(gè)月行輔助性外放療,tPSA降至0.2μg/L,1例術(shù)后18個(gè)月出現(xiàn)生化復(fù)發(fā),行輔助性外放療,tPSA降至4.0μg/L。16例術(shù)后均尿控良好。行藥物去勢(shì)治療5例中,2例分別于治療63、65個(gè)月內(nèi)死亡；1例治療4個(gè)月后,PSA降至2.0μg/L；1例治療24個(gè)月出現(xiàn)去勢(shì)抵抗,行輔助性外放療；1例失訪。 結(jié)論： 年齡50歲的前列腺腺癌臨床分期早,Gleason評(píng)分高。對(duì)腫瘤局限的患者,應(yīng)首選根治性前列腺切除術(shù)治療。晚期患者疾病進(jìn)展較快,預(yù)后較差。
[Abstract]:Objective: prostate adenocarcinoma is a common malignant tumor in elderly men. Methods: the clinical data of 21 patients with prostate adenocarcinoma from January 2008 to March 2014 were analyzed retrospectively. At the time of diagnosis, the age was 42 to 49 years old, the median value was 48 years old. TPSA10 渭 g / L 17 cases were 410 渭 g / L 4 cases. 21 cases were confirmed by pathological diagnosis. Gleason score was 6 points in 3 cases, 7 cases in 6 cases and 34 minutes in 5 cases (43 minutes), 8 points in 7 cases and 9 minutes in 5 cases. Clinical stage T2N0M0: T3NoMo: 1 case of T4NxM0, 1 case of T3-4N1M1, 3 cases of T3-4N1M1, 16 cases of T2N0M0, 15 cases of stage T3N0Mo) underwent radical prostatectomy and 5 cases of drug castration. Results: 16 cases underwent radical prostatectomy, followed up for 3-65 months. The median value of 23 months was 23 months and 14 cases had no biochemical recurrence. One case received adjuvant external radiotherapy to 0.2 渭 g 路L ~ (-1) / L of adjuvant external radiotherapy for 1 month after operation, and one case had biochemical recurrence at 18 months after operation, and the postoperative urine control was good in all the cases treated with adjuvant external radiotherapy to 4.0 渭 g / L.16. Of the 5 cases treated with drug castration, 2 cases died within 63 months and 65 months respectively. After 4 months of treatment, PSA decreased to 2.0 渭 g / L in 1 case, and castration resistance occurred in 1 case after 24 months of treatment. Conclusion: the clinical stage of prostatic adenocarcinoma aged 50 years is early and the Gleason score is high. Radical prostatectomy should be the first choice for patients with localized tumors. Patients with advanced stage of disease progress faster, poor prognosis.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R737.25

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 劉章順;胡曉勇;俞建軍;陳捷;;50歲以下前列腺癌11例報(bào)告并文獻(xiàn)復(fù)習(xí)[J];臨床泌尿外科雜志;2014年04期

2 葉定偉;顧成元;;從大樣本臨床研究看PSA篩查檢出前列腺癌的意義[J];現(xiàn)代泌尿外科雜志;2014年02期

3 向s，

本文編號(hào)：1993926