本文選題：狼瘡性腎炎 + 系統(tǒng)性紅斑狼瘡　； 參考：《川北醫(yī)學(xué)院》2017年碩士論文

【摘要】：目的:通過(guò)測(cè)定狼瘡性腎炎(LN)患者血清中腫瘤壞死因子樣配體1A(TL1A)的水平,探討TL1A在LN患者的臨床意義。方法:選取狼瘡性腎炎患者60例作為實(shí)驗(yàn)組,并選擇34例性別、年齡相匹配的健康者作為對(duì)照組,運(yùn)用酶聯(lián)免疫吸附法(ELISA)測(cè)定血清中TL1A的水平。采用t檢驗(yàn)分析不同組血清TL1A水平差異性,采用Spearman相關(guān)性檢驗(yàn)分析血清TL1A水平與疾病活動(dòng)度、實(shí)驗(yàn)室指標(biāo)等的相關(guān)性。結(jié)果:1.LN患者血清TL1A水平(827.80±235.84pg/ml)較健康對(duì)照組血清水平(589.26±87.31pg/ml)顯著升高,差異有統(tǒng)計(jì)學(xué)意義(Ρ0.01)。2.LN活動(dòng)組血清TL1A水平高于LN穩(wěn)定組及健康對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(Ρ0.01)。LN穩(wěn)定組血清TL1A水平高于健康對(duì)照組,但差異無(wú)統(tǒng)計(jì)學(xué)意義(P㧐0.05)。3.LN患者血清TL1A水平與SLEDAI、24小時(shí)尿蛋白定量、CRP、anti-dsDNA、Anu A呈正相關(guān);與補(bǔ)體3、補(bǔ)體4、白蛋白呈負(fù)相關(guān);與ESR、血肌酐、C1q、抗C1q抗體水平無(wú)相關(guān)性,結(jié)論:TL1A可能參與了LN的發(fā)生與發(fā)展,LN患者血清TL1A水平升高且與疾病活動(dòng)度相關(guān),可根據(jù)其血清水平來(lái)判斷病情、選擇治療方案。
[Abstract]:Objective: to investigate the clinical significance of TL1A in LN patients by measuring the level of TNF- 偽 ligand 1Atl 1A in serum of patients with lupus nephritis (LN). Methods: 60 patients with lupus nephritis were selected as experimental group and 34 healthy persons with matched sex and age as control group. Serum TL1A levels were measured by Elisa. T test was used to analyze the difference of serum TL1A level in different groups, and Spearman correlation test was used to analyze the correlation between serum TL1A level and disease activity, laboratory indexes and so on. Results 1. The serum TL1A level of LN patients was 827.80 鹵235.84pg / ml, which was significantly higher than that of healthy control group (589.26 鹵87.31pg / ml). The serum TL1A level in LN active group was higher than that in LN stable group and healthy control group. There was significant difference in serum TL1A level between stable group and healthy control group, but there was no significant difference between serum TL1A level and 24 hour urinary protein quantification of SLEDAI, complement 3, complement 4 and albumin. There was no correlation between the level of serum creatinine C _ 1Q and anti-C _ 1q antibody. Conclusion: TL1A may be involved in the pathogenesis and development of LN, and may be associated with the increase of serum TL1A level and disease activity, so we can judge the condition according to the serum level of LN and choose the treatment plan.
【學(xué)位授予單位】：川北醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R593.242

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