本文選題：腎炎康復(fù)片 + 標(biāo)準(zhǔn)激素��； 參考：《中國(guó)實(shí)驗(yàn)方劑學(xué)雜志》2015年21期

【摘要】：目的:探討腎炎康復(fù)片輔助標(biāo)準(zhǔn)激素治療氣陰兩虛型腎病綜合征(NS)的臨床療效以及對(duì)血小板數(shù)量(PLT)和血漿垂體腺苷酸環(huán)化酶激活肽(PACAP)的影響。方法:152例NS患者參照隨機(jī)按分層隨機(jī)法分為治療組80例和對(duì)照組72例;兩組患者均采取常規(guī)支持治療和對(duì)癥處理;對(duì)照組采用潑尼松,首始劑量l mg·kg-1·d-1,最大劑量不超過(guò)60 mg·d-1,連續(xù)口服8~12周,再以每2周減少原使用量的10%內(nèi)服,最后以10 mg·d-1的劑量維持治療,根據(jù)具體情況維持6~12個(gè)月,同時(shí)給予對(duì)癥治療。治療組在對(duì)照組治療的基礎(chǔ)上加服腎炎康復(fù)片,5片/次,3次/d,兩組均連續(xù)治療12個(gè)月。檢測(cè)治療前后兩組患者的24 h尿蛋白定量,血清白蛋白(ALB),總膽固醇(TC)和甘油三脂(TG)水平;監(jiān)測(cè)兩組肝功能,記錄治療過(guò)程中不良反應(yīng)發(fā)生率;比較兩組治療前后中醫(yī)(TCM)單項(xiàng)癥狀評(píng)分;檢測(cè)兩組治療前后PLT和血漿PACAP水平。結(jié)果:治療組臨床總有效率為97.5%,對(duì)照組為79.17%,治療組明顯優(yōu)于對(duì)照組(P0.01);治療組治療后24 h尿蛋白定量,TG和TC水平明顯低于對(duì)照組,血清ALB水平顯著高于對(duì)照組(P0.01);治療后治療組患者的向心性肥胖和總體不良反應(yīng)發(fā)生率明顯少于對(duì)照組(P0.05);治療組治療后TCM各單項(xiàng)指標(biāo)評(píng)分均明顯低于對(duì)照組,比較差異均有統(tǒng)計(jì)學(xué)意義(P0.01);治療組治療后PLT數(shù)量明顯低于對(duì)照組,血漿PACAP水平顯著高于對(duì)照組,比較差異均有統(tǒng)計(jì)學(xué)意義(P0.01)。結(jié)論:腎炎康復(fù)片輔助標(biāo)準(zhǔn)激素治療氣陰兩虛型NS能提高臨床療效,減少不良反應(yīng)發(fā)生,降低患者血小板數(shù)量和升高血漿PACAP水平。
[Abstract]:Objective: to investigate the clinical efficacy of nephritis rehabilitation tablets in the treatment of Nephrotic Syndrome with deficiency of Qi and Yin (NSN) and its effects on platelet count and plasma adenylate cyclase activating peptide (PACAP). Methods 152 cases of NS were randomly divided into treatment group (n = 80) and control group (n = 72). The first dose was 1 mg kg-1 d -1 and the maximum dose was not more than 60 mg d -1. The first dose was taken orally for 812 weeks, then 10% of the original dosage was reduced every 2 weeks. Finally, the dosage of 10 mg d -1 was maintained for 6 ~ 12 months according to the specific conditions, and the symptomatic treatment was given at the same time. On the basis of the treatment in the control group, the treatment group was given 5 tablets of nephritis rehabilitation tablet / 3 times / d, and both groups were treated continuously for 12 months. Before and after treatment, the levels of 24 h urine protein, serum albumin, total cholesterol (TCC) and triglyceride (TG) were measured, liver function was monitored and the incidence of adverse reactions was recorded. The single symptom score of TCM was compared before and after treatment, and the levels of PLT and plasma PACAP were measured before and after treatment. Results: the total clinical effective rate of the treatment group was 97.5 and that of the control group was 79.17, which was obviously superior to that of the control group (P 0.01), and the levels of TG and TC in the treatment group 24 h after treatment were significantly lower than those in the control group. The level of serum ALB was significantly higher than that of control group (P 0.01), the incidence of cardiac obesity and total adverse reactions in the treatment group was significantly lower than that in the control group (P 0.05), and the score of each single index of TCM in the treatment group was significantly lower than that in the control group. The amount of PLT in the treatment group was significantly lower than that in the control group, and the plasma PACAP level was significantly higher than that in the control group. Conclusion: the treatment of NS with deficiency of Qi and Yin by the auxiliary standard hormone of nephritis rehabilitation tablet can improve the clinical efficacy, reduce the occurrence of adverse reactions, reduce the platelet count and increase the plasma PACAP level.
【作者單位】： 淄博市中心醫(yī)院;山東省立醫(yī)院;
【基金】：淄博市科技局青年基金項(xiàng)目(2013A100541)
【分類(lèi)號(hào)】：R692

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