本文選題：膜性腎病 + 特發(fā)性膜性腎病�。� 參考：《醫(yī)學(xué)研究生學(xué)報(bào)》2017年07期

【摘要】：在PLA2R1及其抗體研究的基礎(chǔ)上,1型血小板7A域及其抗體的發(fā)現(xiàn)使人們對(duì)膜性腎病又有了新的認(rèn)識(shí)。THSD7A是在PLA2R1陰性的膜性腎病患者中發(fā)現(xiàn)的,故有部分研究報(bào)道提出PLA2R1與THSD7A的自身抗體在膜性腎病中相互排斥,但最新研究表明,THSD7A可與PLA2R1在膜性腎病患者中共存,呈現(xiàn)雙陽性。與PLA2R1類似,THSD7A對(duì)膜性腎病具有指導(dǎo)診斷、治療、監(jiān)測等意義。與PLA2R1不同的是,THSD7A在人類和嚙齒類動(dòng)物的腎小球中均高度表達(dá),故未來可利用小鼠模型研究THSD7A相關(guān)性膜性腎病的發(fā)病機(jī)制。文章就THSD7A及其抗體的結(jié)構(gòu)、作用、與膜性腎病之間的關(guān)系及應(yīng)用前景的研究進(jìn)展進(jìn)行綜述。
[Abstract]:Based on the study of PLA2R1 and its antibody, the discovery of type 1 platelet 7A domain and its antibody makes people have a new understanding of membranous nephropathy. THSD7A is found in patients with PLA2R1 negative membranous nephropathy. Therefore, some studies have reported that autoantibodies of PLA2R1 and THSD7A repel each other in membranous nephropathy, but the latest studies show that THSD7A and PLA2R1 co-exist in patients with membranous nephropathy and present double positive. Similar to PLA2R1, THSD 7 A has guiding significance in the diagnosis, treatment and monitoring of membranous nephropathy. Different from PLA2R1, THSD7A is highly expressed in human and rodent glomeruli, so we can use mouse model to study the pathogenesis of THSD7A associated membranous nephropathy in the future. In this paper, the structure, function, relationship between THSD7A and its antibodies to membranous nephropathy and their application prospect are reviewed.
【作者單位】： 南京醫(yī)科大學(xué)附屬無錫人民醫(yī)院檢驗(yàn)科;江蘇省原子醫(yī)學(xué)研究所;
【基金】：江蘇省科技廳項(xiàng)目(BL2014022)
【分類號(hào)】：R692

【參考文獻(xiàn)】

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1 錢玉s，

本文編號(hào)：1939539