本文選題：良性前列腺增生 + 儲(chǔ)尿期癥狀　； 參考：《中華男科學(xué)雜志》2017年09期

【摘要】：目的:探討儲(chǔ)尿期癥狀明顯的重度良性前列腺增生(BPH)患者經(jīng)尿道前列腺電切術(shù)(TURP)后口服M-受體阻滯劑的用藥方案及其臨床效果。方法:儲(chǔ)尿期癥狀明顯的重度BPH患者,TURP 6 h后開(kāi)始口服酒石酸托特羅定片(2 mg每12 h 1次或4 mg 1次/d),4周后停藥,如儲(chǔ)尿期癥狀加重,繼續(xù)服藥2周再停藥觀察,如此反復(fù)直至術(shù)后12周�；仡櫺苑治銎湫g(shù)前,術(shù)后1、4、8、12周IPSS評(píng)分(總分、儲(chǔ)尿期、排尿期癥狀評(píng)分)、QoL評(píng)分、Qmax和排尿后膀胱殘余尿(PVR)。結(jié)果:臨床資料完備病例共106例。其中4周停藥后儲(chǔ)尿期癥狀未加重(成功停藥)者33例,6~8周成功停藥者51例,10~12周成功停藥者13例,12周后仍需繼續(xù)服藥者9例。術(shù)前,術(shù)后1、4、8、12周IPSS總分分別為(25.33±3.45)、(19.33±3.62)、(11.56±2.45)、(8.38±2.08)、(7.74±1.87)分;儲(chǔ)尿期IPSS分別為(11.97±1.53)、(10.76±1.82)、(6.16±1.22)、(4.08±1.19)、(3.91±1.15)分;排尿期IPSS分別為(9.80±1.60)、(5.59±1.45)、(3.40±0.92)、(2.85±0.71)、(2.61±0.67)分;QoL評(píng)分為(4.70±0.78)、(3.92±0.75)、(2.55±0.74)、(1.83±0.72)、(1.66±0.75)分;除術(shù)后12周與術(shù)后8周比較外,術(shù)前、術(shù)后各觀察點(diǎn)之間,IPSS各項(xiàng)指標(biāo)均有顯著性差異(P均0.01)。QoL、Qmax、PVR術(shù)后1、4周呈現(xiàn)進(jìn)行性改善(P均0.01),4周后變化不再顯著(P均0.05)。結(jié)論:儲(chǔ)尿期癥狀明顯的重度BPH患者TURP術(shù)后持續(xù)口服M-受體阻滯劑4~8周可能是治療其術(shù)后儲(chǔ)尿期癥狀的有效方案。
[Abstract]:Objective: to investigate the clinical effect of oral M- receptor blocker after transurethral resection of prostate (TURP) in patients with severe benign prostatic hyperplasia (BPH). Methods: the patients with severe BPH who had obvious symptoms in the period of urinary storage were treated with TURP 6 h later, and then they were given tolterodine tartrate 2 mg every 12 h or 4 mg / d after 4 weeks. If the symptoms in the period of urine storage became more serious, the patients should continue to take the drug for 2 weeks and then stop taking the drug for 2 weeks. It was repeated until 12 weeks after the operation. The preoperative and postoperative IPSS scores (total score, urine storage stage, urination symptom score, Qmax) and residual bladder urine (PVRV) after urination were analyzed retrospectively in 12 weeks (total score, urine storage stage, urination stage score, Qmax) and residual bladder urine after micturition (P < 0.05). Results: there were 106 cases with complete clinical data. Among them, 33 cases (successful withdrawal) after 4 weeks withdrawal of urine (successful withdrawal), 51 cases (51 / 10 / 12 weeks) successfully stopped the drug, 13 cases (13 / 12) still need to continue taking the drug after 12 weeks. 鏈墠,鏈悗1,4,8,12鍛↖PSS鎬誨垎鍒嗗埆涓，

本文編號(hào)：1911632