發(fā)布時(shí)間：2018-05-07 16:50

  本文選題：免疫性腎小球疾病 + 他克莫司��； 參考：《醫(yī)學(xué)與哲學(xué)(B)》2017年05期

【摘要】：對(duì)單用他克莫司和聯(lián)合五酯膠囊治療免疫性腎小球疾病療效、安全性和藥物-經(jīng)濟(jì)效益進(jìn)行比較。回顧性分析大連醫(yī)科大學(xué)附屬第一醫(yī)院2011年1月~2015年12月行腎活檢證實(shí)為免疫性腎小球疾病并伴大量蛋白尿的患者60例,分為單用他克莫司組和聯(lián)合五酯膠囊組。主要評(píng)價(jià)指標(biāo):蛋白尿緩解率、各個(gè)時(shí)間點(diǎn)蛋白尿緩解率等;次要評(píng)價(jià)指標(biāo):藥物副作用、治療費(fèi)用及藥物-經(jīng)濟(jì)學(xué)效益。隨訪第3個(gè)月、6個(gè)月,他克莫司聯(lián)合五酯膠囊組蛋白尿緩解人數(shù)高于單用他克莫司組(P0.05),兩組副作用無差異(P0.05),而治療費(fèi)用及成本-療效比有統(tǒng)計(jì)學(xué)差異(P0.05);他克莫司聯(lián)合五酯膠囊可有效降低免疫性腎小球疾病蛋白尿,且具有較好藥物經(jīng)濟(jì)學(xué)效益。
[Abstract]:The efficacy, safety and pharmaco-economic benefit of tacrolimus and pentyl ester capsules in the treatment of immune glomerular diseases were compared. From January 2011 to December 2015, 60 patients with immunologic glomerular disease and large proteinuria were analyzed retrospectively. They were divided into two groups: tacrolimus group and combined pentyl ester capsule group. Main outcome measures: remission rate of proteinuria, remission rate of proteinuria at different time points, secondary evaluation measures: side effects of drugs, treatment costs and pharmaco-economic benefits. They were followed up for 3 months, 6 months, The remission of proteinuria in tacrolimus combined with pentyl ester capsule group was higher than that in tacrolimus group alone, and there was no difference in side effects between the two groups (P 0.05), while there was significant difference in the cost of treatment and the ratio of cost to curative effect (P 0.05), and tacrolimus combined with pentyl ester capsule was effective in reducing the incidence of proteinuria. Low immune glomerular disease proteinuria, And has good pharmacoeconomics benefit.
【作者單位】： 大連醫(yī)科大學(xué)附屬第一醫(yī)院腎內(nèi)科;
【分類號(hào)】：R692.6

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