本文選題：膀胱過度活動(dòng)癥 + M受體阻滯劑��； 參考：《重慶醫(yī)科大學(xué)學(xué)報(bào)》2015年10期

【摘要】：目的:系統(tǒng)評(píng)價(jià)M受體阻滯劑聯(lián)合非藥物方式治療成年女性膀胱過度活動(dòng)癥(overactive bladder,OAB)的療效及臨床價(jià)值。方法:檢索2015年1月前在Pub Med、Embase、Web of Science以及相關(guān)期刊論文(CNKI)和中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(CBWMDisc)等已公開發(fā)表的關(guān)于M受體阻滯劑聯(lián)合非藥物與單用M受體阻滯劑相比治療成年女性膀胱過度活動(dòng)癥(OAB)的隨機(jī)對(duì)照試驗(yàn),通過納入標(biāo)準(zhǔn)和排除標(biāo)準(zhǔn)篩選文獻(xiàn)。按照J(rèn)adad量表評(píng)價(jià)納入研究的質(zhì)量,采用Revman5.3進(jìn)行meta分析。結(jié)果:共有7篇文獻(xiàn)(共610例)符合納入標(biāo)準(zhǔn)。其中M受體阻滯劑聯(lián)合電刺激4篇,聯(lián)合行為訓(xùn)練2篇,聯(lián)合電刺激加行為訓(xùn)練1篇。Meta分析結(jié)果顯示:(1)與對(duì)照組(單用M受體阻滯劑組)相比,M受體阻滯劑聯(lián)合電刺激在降低日平均排尿次數(shù)(WMD=-0.60,95%CI=-1.23~0.03,P=0.06)、尿失禁次數(shù)(SMD=-4.45,95%CI=-12.77~3.86,P=0.29)方面療效無統(tǒng)計(jì)學(xué)差異;但在降低尿急次數(shù)(WMD=-1.09,95%CI=-2.15~-0.03,P=0.04),提高臨床總有效率(RR=1.24,95%CI=1.06~1.44,P=0.007)方面,M受體阻滯劑聯(lián)合電刺激療效優(yōu)于對(duì)照組。(2)M受體阻滯劑聯(lián)合行為訓(xùn)練在降低日平均排尿次數(shù)方面療效優(yōu)于對(duì)照組(WMD=-0.67,95%CI=-1.14~-0.20,P=0.005)。結(jié)論:M受體阻滯劑聯(lián)合非藥物治療方式較單用M受體阻滯劑能夠更好地改善成年女性O(shè)AB患者的部分排尿癥狀,提高臨床總有效率。
[Abstract]:Objective: to evaluate the efficacy and clinical value of M receptor blocker combined with non-drug therapy in the treatment of overactive bladder hyperactivity syndrome (OAB) in adult women. Methods: to search for the M receptor blockers combined with non-drugs and single M receptor blockers published before January 2015 in Pub Medbase of Science and China Journal Full-text Database (CNKI) and Chinese Biomedical Literature Database (CBWM Disc). A randomized controlled trial compared with OAB for adult women with bladder hyperactivity. The literature was screened by inclusion criteria and exclusion criteria. According to the quality of Jadad scale, Revman5.3 was used for meta analysis. Results: a total of 7 articles (610 cases) met the inclusion criteria. Among them, M receptor blockers combined with electrical stimulation (4 articles) and behavioral training (2 articles), The results of combined electrical stimulation and behavioral training 1 .Meta analysis showed that compared with the control group (M receptor blocker group) and the control group (M receptor blocker group), there was no significant difference in the effect of combined electrical stimulation with M receptor blocker on reducing the daily average urination times (WMD-0.60 ~ 95CI-1.23CI-0.03), urinary incontinence (SMD-4.455) and urinary incontinence (SMD-4.455CI-1 / 12.773.86 P0.29). However, in reducing the times of urinal urgency, WMD-1.09 ~ 95CI-2.15- 0.03P0.04, and improving the total clinical effective rate, the effect of combined electrical stimulation with RRMreceptor blocker was better than that of the control group in reducing the average daily urination times. The effect of combined action training of the group was superior to that of the control group in reducing the daily average urination times. The therapeutic effect was better than that of WMD-0.6795CI-1.14- 0.20P0.005. the effect of electrical stimulation was better than that of the control group (WMD-0.6795CI-1.14- 0.20g / kg P0. 005N) in decreasing the number of times of urination in the control group (P < 0. 05), but the effect was better than that in the control group. Conclusion compared with the single use of M-receptor blockers, the micturition symptoms of adult female patients with OAB can be improved better and the total clinical effective rate can be improved by the combination of fraction M receptor blocker and non-drug therapy.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第二醫(yī)院泌尿外科;
【分類號(hào)】：R694

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 張廣濤;包振虎;張連棟;;索利那新聯(lián)合電刺激治療女性膀胱過度活動(dòng)癥的療效[J];實(shí)用醫(yī)學(xué)雜志;2012年23期

2 繆子敬;陸v炄，

本文編號(hào)：1840322