本文選題：慢性腎臟疾病 + 肥胖　； 參考：《上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年09期

【摘要】：目的·研究中國(guó)中老年社區(qū)人群肥胖與慢性腎臟疾病(CKD)的相關(guān)性。方法·采取整群抽樣的方法對(duì)上海市嘉定區(qū)10 375名40歲及以上的常住居民進(jìn)行調(diào)查。每位受試者均接受標(biāo)準(zhǔn)化問(wèn)卷調(diào)查、體格檢查,同時(shí)采集空腹血和晨尿標(biāo)本檢測(cè)血糖、血脂、肝功能、腎功能、尿白蛋白、尿肌酐等生化指標(biāo)。肥胖程度的判斷采用世界衛(wèi)生組織(WHO)的診斷標(biāo)準(zhǔn),將男性和女性按照體質(zhì)量指數(shù)(BMI)分為正常體質(zhì)量組(BMI25 kg/m~2)、超重組(25 kg/m2≤BMI30 kg/m2)、肥胖組(BMI≥30 kg/m2)。依據(jù)美國(guó)CKD流行病學(xué)合作研究組(CKD-EPI)方程計(jì)算獲得估算的腎小球?yàn)V過(guò)率。采用Logistic回歸分析不同BMI水平人群CKD的患病風(fēng)險(xiǎn)。結(jié)果·研究對(duì)象各項(xiàng)代謝指標(biāo)均隨著BMI水平的升高而趨向惡化。在校正多種因素后,BMI每增加1 kg/m2,CKD患病風(fēng)險(xiǎn)增加9%,其比值比(OR)為1.09(95%CI:1.07~1.12)。多元Logistic回歸分析結(jié)果顯示,超重組和肥胖組的CKD患病風(fēng)險(xiǎn)較正常體質(zhì)量組分別增加51%(OR=1.51,95%CI:1.27~1.78)和181%(OR=2.81,95%CI:2.20~3.61)。結(jié)論·在中國(guó)中老年社區(qū)人群中,超重和肥胖者CKD患病風(fēng)險(xiǎn)顯著升高。
[Abstract]:Objective to study the correlation between obesity and chronic renal disease (CKD) in Chinese middle-aged and elderly community. Methods A cluster sampling method was used to investigate 10 375 residents aged 40 and above in Jiading District, Shanghai. Each of the subjects received standardized questionnaire, physical examination, fasting blood samples and morning urine samples to detect blood glucose, blood lipid, liver function, renal function, urinary albumin, urinary creatinine and other biochemical indicators. According to body mass index (BMI), male and female were divided into two groups: normal body mass group (BMI) 25 kg / m ~ (-2), superrecombinant 25 kg/m2 鈮，

本文編號(hào)：1798050