本文選題：肌層浸潤性膀胱癌 + 經尿道膀胱腫瘤電切術��； 參考：《吉林大學》2014年碩士論文

【摘要】：目的：探討表柔比星與羥喜樹堿膀胱灌注在預防肌層浸潤性胱癌行經尿道膀胱腫瘤電切術后復發(fā)的臨床療效及安全性。 方法：選取行經尿道膀胱腫瘤電切術（TUR-BT）的膀胱癌患者，根據術后病理與患者及患者家屬的意愿選擇符合要求的43例肌層浸潤性膀胱癌患者，將43例患者隨機分成兩組，A組23例患者（表柔比星組），B組20例患者（羥喜樹堿組），術后24小時內行表柔比星50mg（或者羥喜樹堿40mg）+生理鹽水20ml膀胱灌注化療，1h后開放尿管，術后1周起采用原劑量行膀胱內灌注化療。表柔比星灌注方案為1次/周，連續(xù)8周，然后1次/月×10次，共1年，羥喜樹堿灌注化療方案為1次/周，連續(xù)8周，然后1次/2周×8次，再行1次/月×18次，共2年。隨訪比較兩組患者術后腫瘤復發(fā)及發(fā)生并發(fā)癥情況。 結果：43例患者的治療隨訪時間為13—44個月，肌層浸潤性膀胱腫瘤患者應用表柔比星與羥喜樹堿在比較1年內復發(fā)率各為13.0%，20.0%，2年內復發(fā)率各為34.8%，30.0%，均無統(tǒng)計學差異（P＞0.05），兩者在預防膀胱腫瘤復發(fā)中均無明顯的優(yōu)越性。 結論：肌層浸潤性膀胱癌患者行經尿道膀胱腫瘤電切術后并長期規(guī)律膀胱灌注表柔比星或羥喜樹堿治療達到了較為滿意的療效，膀胱內灌表柔比星和羥喜樹堿化療藥物安全性與臨床耐受性良好，患者手術指征掌握恰當，并且術后注意密切隨訪與復查，可顯著提高患者術后的生活質量。
[Abstract]:Objective: to investigate the clinical efficacy and safety of epirubicin and hydroxycamptothecin in preventing recurrence of myometrial invasive cystoma after transurethral resection of bladder tumor.Methods: patients with bladder cancer underwent transurethral resection of bladder tumor (TUR-BT). According to the postoperative pathology and the wishes of the patients and their families, 43 patients with myometrial invasive bladder cancer were selected.43 patients were randomly divided into two groups: group A (n = 23) (epirubicin group, n = 20), group B (n = 20) (hydroxycamptothecin group, n = 20). Within 24 hours after operation, 30 mg of epirubicin (or 40 mg of hydroxycamptothecin) were given intravesical infusion chemotherapy of epirubicin (50 mg) or hydroxycamptothecin (40 mg).Intravesical infusion chemotherapy was performed 1 week after operation.Epirubicin was given once a week for 8 weeks, then once a month 脳 10 times for a total of 1 year. Hydrocamptothecin infusion regimen was given once a week for 8 weeks, then 1 / 2 weeks 脳 8 times, and 1 / month 脳 18 times for 2 years.Tumor recurrence and complications were compared between the two groups.Results 43 patients were followed up for 13-44 months.The recurrence rates of epirubicin and hydroxycamptothecin in patients with intramuscular invasive bladder tumor were 13.0% 20.0 in 1 year and 30.0% in 2 years, respectively. There was no significant difference between them (P > 0.05). There was no obvious superiority in preventing the recurrence of bladder tumor between the two groups.Conclusion: after transurethral resection of bladder neoplasms and long-term regular bladder instillation of epirubicin or hydroxycamptothecin in patients with myometrial invasive bladder cancer, satisfactory results have been achieved.The safety and clinical tolerance of intravesical instillation of epirubicin and hydroxycamptothecin were good.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R737.14

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