本文選題：輸尿管結(jié)石 + α受體阻滯劑�。� 參考：《新疆醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的:應(yīng)用α受體阻滯劑坦索羅辛和阿呋唑嗪治療輸尿管結(jié)石，進行前瞻性隨機對照研究，對坦索羅辛和阿呋唑嗪治療輸尿管結(jié)石的臨床療效對比，從而為臨床合理用藥提供依據(jù)。方法:選取2013年10月—2014年6月，我院泌尿外科門診臨床表現(xiàn)、體征、相關(guān)實驗室檢查及影像學(xué)檢查確證為輸尿管結(jié)石的患者304例患者入組，根據(jù)隨機數(shù)字表法隨機分為A試驗組（阿呋唑嗪）和B對照組（坦索羅辛）。所有患者在治療期間保持每日尿量2000ml～3000ml。詳細(xì)記錄每例患者的結(jié)石位置，大小等，每位患者臨床檢查結(jié)石排出，或者經(jīng)過臨床醫(yī)生會診需要改為手術(shù)治療的為記錄和研究結(jié)束點。腎絞痛的患者應(yīng)用數(shù)字疼痛評分法（NRS），以觀察臉部表情及詢問主觀感受的方法來綜合評價患者疼痛的癥狀。結(jié)果:試驗組患者為160例,男性131例,女性29例,年齡21歲~61歲,平均年齡37.33±10.12歲；對照組患者為160例,男性120例,女性40例,年齡19歲~60歲,平均年齡37.44±11.12歲。試驗組和對照組均能促進結(jié)石排出，對照組在結(jié)石排出率和排出時間方面較試驗組有顯著性差異（P＜0.05），試驗組與對照組總療效有顯著性差異（P＜0.05）；試驗組和對照組對輸尿管上段和中段結(jié)石的排出率與排石時間沒有顯著性差異（P0.05），對下段結(jié)石排出率和排出時間有顯著性差異（P＜0.05）；試驗組和對照組對≤5mm結(jié)石的排出率沒有顯著性差異（P0.05），而對排出時間有顯著性差異（P＜0.05）；對≥5mm結(jié)石的排出率及排出時間均有有顯著性差異（P＜0.05），試驗組和對照組對腎絞痛緩解率有顯著性差異（P＜0.05）。試驗組和對照組不良反應(yīng)沒有顯著性差異（P0.05）。對照組優(yōu)于試驗組藥物的成本-效果。結(jié)論:1.坦索羅辛和阿呋唑嗪均能促進輸尿管結(jié)石的排出，縮短結(jié)石排出的時間。2.坦索羅辛和阿呋唑嗪對輸尿管上段和中段的結(jié)石排出率及排出時間兩藥無明顯差異，對輸尿管下段結(jié)石，坦索羅辛優(yōu)于阿呋唑嗪�？偟呐攀熜П容^，坦索羅辛優(yōu)于阿呋唑嗪。3.對于小于或等于5mm的輸尿管結(jié)石，坦索羅辛和阿呋唑嗪均能促進結(jié)石的排出，，縮短結(jié)石排出時間，但坦索羅辛較阿呋唑嗪能明顯的縮短結(jié)石排出時間；對于大于或等于5mm的輸尿管結(jié)石，坦索羅辛排石的效果優(yōu)于阿呋唑嗪。4.坦索羅辛在緩解腎絞痛方面優(yōu)于阿呋唑嗪。5.坦索羅辛和阿呋唑嗪對輸尿管結(jié)石的治療是安全有效的，無明顯的、新發(fā)的不良反應(yīng),兩藥的不良反應(yīng)無明顯差異。6.坦索羅辛的成本-效果優(yōu)于阿呋唑嗪。
[Abstract]:Objective: to treat ureteral calculi with 偽 receptor blocker tamsoloxine and alfuzosin, and to compare the clinical efficacy of tamsoloxine and alfuzosin in the treatment of ureteral calculi.So as to provide the basis for clinical rational use of drugs.Methods: 304 patients with ureteral calculi were selected from October 2013 to June 2014.According to the random number table method, the patients were randomly divided into A group (alfuzosin) and B control group (tamsoloxine).All patients maintained a daily urine volume of 2000ml / 3000ml during treatment.The location, size, etc of each patient's stone were recorded in detail, and each patient's clinical examination of stone excretion, or the clinician consultation needs to be changed to surgical treatment for the end of the record and research point.Patients with renal colic were evaluated with digital pain score (NRSs). The symptoms of pain were evaluated by observing facial expressions and asking subjective feelings.Results: there were 160 patients, 131 males and 29 females, aged 21 years or 61 years, with an average age of 37.33 鹵10.12 years in the trial group, and 160 patients, 120 males and 40 females, aged from 19 to 60 years with an average age of 37.44 鹵11.12 years in the control group.Both the experimental group and the control group could promote the excretion of stones.There were significant differences in stone excretion rate and time between the control group and the experimental group (P < 0.05), the total curative effect between the test group and the control group was significant (P < 0.05), and the excretion rate of the upper and middle ureteral calculi in the test group and the control group was lower than that in the control group (P < 0.05).There was no significant difference between the two groups (P < 0.05, P < 0.05), but there was no significant difference between the test group and the control group in the excretion rate of 鈮

本文編號：1751951