本文選題：良性前列腺增生　切入點(diǎn)：前列欣膠囊　出處：《中國藥房》2017年08期

【摘要】：目的:觀察前列欣聯(lián)合鹽酸坦索羅辛和非那雄胺治療老年良性前列腺增生的臨床療效。方法:選擇2012年5月-2014年10月我院確診為良性前列腺增生的老年患者94例,根據(jù)入院單雙號(hào)分為觀察組(48例)和對(duì)照組(46例)。兩組患者均給予非那雄胺片5 mg,po,qd,對(duì)照組患者在此基礎(chǔ)上加用鹽酸坦索羅辛緩釋膠囊0.2 mg,po,qd;觀察組患者在對(duì)照組基礎(chǔ)上加用前列欣膠囊2.5 g,po,tid。兩組患者均連續(xù)治療3個(gè)月。觀察兩組患者臨床療效及治療前后國際前列腺癥狀量表(IPSS)評(píng)分、泌尿癥狀困擾評(píng)分(BS)、勃起功能國際問卷(IIEF-5)評(píng)分、超聲測量指標(biāo)和中醫(yī)證候評(píng)分。結(jié)果:觀察組患者臨床總有效率為93.75%,顯著高于對(duì)照組的76.09%,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,兩組患者IPSS、BS、IIEF-5評(píng)分及超聲測量指標(biāo)、中醫(yī)證候評(píng)分比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,兩組患者IPSS、BS、前列腺體積(PV)、殘余尿量(RU)、中醫(yī)證候各項(xiàng)評(píng)分及總分均顯著降低,IIEF-5評(píng)分、最大尿流率(Qmax)顯著升高,且觀察組明顯優(yōu)于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:前列欣聯(lián)合鹽酸坦索羅辛和非那雄胺治療老年良性前列腺增生療效顯著,有助于改善良性前列腺增生老年患者的前列腺癥狀和中醫(yī)證候,減小PV和RU,改善性功能。
[Abstract]:Objective: to observe the clinical efficacy of Qianliexin combined with tamsoloxine hydrochloride and finasteride in the treatment of benign prostatic hyperplasia in the elderly. Methods: 94 elderly patients with benign prostatic hyperplasia diagnosed in our hospital from May 2012 to October 2014 were selected. The patients in both groups were treated with fenasteride tablets (5 mg / kg) and control group (n = 46). The patients in the control group were treated with tansoloxine hydrochloride sustained release capsule (0.2 mg / kg) and the patients in the control group were treated with fenasteride tablets (0.2 mg / kg poqd), and the patients in the control group were treated with fenasteride tablets (0.2 mg / kg poqd). Two groups of patients were treated continuously for 3 months. The clinical efficacy of the two groups and the IPSS scores before and after treatment were observed. Results: the total effective rate of the patients in the observation group was 93.75, which was significantly higher than that in the control group (76.09), and the difference was statistically significant before treatment (P 0.05). There was no significant difference between the two groups in the scores of IPSS BSU IIEF-5, ultrasound and TCM syndromes (P 0.05). After treatment, the scores of IPSS BSs, prostate volume, residual urine volume and residual urine volume were significantly decreased in both groups, and the scores and total scores of TCM syndromes were significantly decreased. The maximum urinary flow rate (Qmax) was significantly increased, and the observation group was significantly better than the control group (P 0.05). Conclusion: Qianliexin combined with tamsoloxine hydrochloride and finasteride are effective in the treatment of benign prostatic hyperplasia in the elderly. It can improve prostate symptoms and TCM syndromes, reduce PV and RUU, and improve sexual function in elderly patients with benign prostatic hyperplasia.
【作者單位】： 河北大學(xué)附屬醫(yī)院中西醫(yī)結(jié)合科;河北大學(xué)附屬醫(yī)院泌尿外科;河北大學(xué)附屬醫(yī)院放療科;河北大學(xué)附屬醫(yī)院康復(fù)醫(yī)學(xué)科;
【分類號(hào)】：R697+.3

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本文編號(hào)：1691994