本文選題：小鼠腎組織　切入點：急性腎損傷　出處：《中國病理生理雜志》2015年10期

【摘要】：正目前,PTGES2在膿毒癥中的作用尚不清楚。本研究首次發(fā)現(xiàn)在LPS刺激后C57BL/6小鼠腎組織中PTGES2的表達較正常對照組明顯增高。采用免疫組織化學方法檢測發(fā)現(xiàn),PTGES2主要定位于近曲小管上皮細胞的細胞漿中,在腎小球和腎髓質未見明顯表達。為了探討PTGES2與自噬的關系,本研究對LPS刺激時小鼠腎組織中自噬接頭蛋白p62的表達進行檢測,結果發(fā)現(xiàn)在LPS刺激后C57BL/6小鼠腎組織中p62的表達較正常對照組明顯降低,與PTGES2的表達呈負相關關系;采用免
[Abstract]:At present, the role of PTGES2 in sepsis is not clear. This study first found that the expression of PTGES2 in renal tissue of C57BL/6 mice after LPS stimulation was significantly higher than that of normal control group. The main localization of PTGES2 was detected by immunohistochemical method. In the cytoplasm of the epithelial cells of the proximal convoluted tubules, In order to investigate the relationship between PTGES2 and autophagy, the expression of autophagy junction protein p62 in renal tissue of mice stimulated by LPS was detected. The results showed that the expression of p62 in renal tissue of C57BL/6 mice after LPS stimulation was significantly lower than that of normal control group, and negatively correlated with the expression of PTGES2.
【作者單位】： 中南大學湘雅醫(yī)學院病理生理學系;
【分類號】：R459.7;R692

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