本文選題：他克莫司　切入點(diǎn)：基因多態(tài)性　出處：《中南大學(xué)》2014年碩士論文

【摘要】：目的：探討MDR1、SLCO1B3基因多態(tài)性對(duì)腎移植術(shù)后他克莫司療效的影響。 方法：選擇中南大學(xué)湘雅三醫(yī)院親屬腎移植術(shù)后3個(gè)月至6個(gè)月穩(wěn)定期患者,男女不限,年齡18歲-65歲。術(shù)后采用他克莫司+霉酚酸酯+皮質(zhì)類固醇激素三聯(lián)免疫抑制治療,EMIT方法檢測他克莫司的全血濃度后計(jì)算出濃度/劑量(C/D)比值。采用PCR-RFLP對(duì)MDR1基因343CT、SLCO1B3基因699GA進(jìn)行基因分型。比較MDR1基因3435CT、LCO1B3基因699GA不同基因型對(duì)他克莫司濃度/劑量(C/D)比值的影響。 結(jié)果：MDR1基因3435CT位點(diǎn)不同基因型術(shù)后他克莫司C/D比值差異無統(tǒng)計(jì)學(xué)意義(P0.05)、SLCO1B3基因699GA位點(diǎn)不同基因型術(shù)后他克莫司C/D比值差異有統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論：SLCO1B3基因699GA不同基因型對(duì)術(shù)后他克莫司C/D比值有影響,突變型純合子AA術(shù)后他克莫司C/D比值較高。
[Abstract]:Objective: to investigate the effect of MDR1 / SLCO1B3 gene polymorphism on the efficacy of tacrolimus after renal transplantation. Methods: male and female patients with stable renal transplantation from 3 months to 6 months after renal transplantation in Xiangya third Hospital of Central South University were selected. After operation, the whole blood concentration of tacrolimus was measured by using the triple immunosuppressive therapy of tacrolimate corticosteroid and corticosteroid. The concentration / dose of tacrolimus was calculated. The MDR1 gene was detected by PCR-RFLP. The effects of different 699GA genotypes of MDR1 gene 3435CTC LCO1B3 on the ratio of tacrolimus concentration to dose of tacrolimus were compared. Results there was no significant difference in the ratio of tacrolimus C / D to tacrolimus after different genotypes at the 3435CT locus of the 1: MDR1 gene. There was no significant difference in the ratio of tacrolimus C / D to tacrolimus in the different genotypes of the 699GA locus. Conclusion different genotypes of 699GA of the 10% SLCO1B3 gene have an effect on the ratio of tacrolimus C / D after operation, and tacrolimus C / D ratio is higher after AA in mutant homozygotes.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R699.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 張鑫,劉志紅,鄭敬民,陳朝紅,唐政,陳勁松,黎磊石;腎移植患者他克莫司血藥濃度的影響因素[J];腎臟病與透析腎移植雜志;2005年04期

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本文編號(hào)：1658115