發(fā)布時(shí)間：2018-03-22 00:15

  本文選題：糖腎方　切入點(diǎn)：貝前列素鈉　出處：《中國(guó)實(shí)驗(yàn)方劑學(xué)雜志》2017年21期 　論文類型：期刊論文

【摘要】：目的:觀察糖腎方聯(lián)合貝前列素鈉對(duì)糖尿病腎病患者(DKD)炎癥因子的影響及安全性。方法:單純應(yīng)用糖腎方(中藥組)、貝前列素鈉(西藥組)與兩者聯(lián)合應(yīng)用(合用組)進(jìn)行隨機(jī)平行對(duì)照研究,觀察各組患者給藥前后臨床療效、中醫(yī)證候積分、空腹血糖(FBG)、尿蛋白排泄率(UAER)及相關(guān)炎性細(xì)胞因子轉(zhuǎn)化生長(zhǎng)因子(TGF)-β1,腫瘤壞死因子(TNF)-α及白細(xì)胞介素(IL)-18等的變化。結(jié)果:與治療前比較,各組治療后各項(xiàng)指標(biāo)均降低;與西藥組比較,中藥組患者FBG水平明顯降低(P0.05);與中藥組比較,西藥組患者IL-18水平明顯降低(P0.05);與中藥組、西藥組比較,合用組患者臨床總有效率升高(P0.05),合用組患者的腎氣虛相關(guān)癥狀(腰膝酸軟、口干不欲飲)積分,FBG水平,UAER水平以及炎癥因子水平均明顯降低(P0.05);與西藥組比較,合用組患者脾氣虛相關(guān)癥狀(納差乏力、肢體浮腫)積分明顯降低(P0.05)。3組患者研究過程中均未發(fā)現(xiàn)嚴(yán)重不良反應(yīng)。結(jié)論:糖腎方與貝前列素鈉聯(lián)用,可提高降低患者尿蛋白,改善炎癥狀態(tài)的作用,對(duì)臨床期DKD有較好的治療效果。
[Abstract]:Objective: to observe the effect and safety of Tangshen recipe combined with beprost sodium on inflammatory factors of diabetic nephropathy patients with DKD. Methods: Tangshen recipe (traditional Chinese medicine group), beprostol sodium (western medicine group) and combined therapy (combined with both) were used. In a randomized, parallel controlled study, Observe the clinical effect before and after administration of drugs, TCM syndrome score, The changes of FBGG, urinary protein excretion rate (UAER-UAER), TGF- 尾 _ 1, TNF- 偽 and IL-IL-18, and so on. Results: compared with those before and after treatment, the indexes of each group were decreased, and those of western medicine group were lower than those of western medicine group, and the changes of TGF- 尾 1, TNF- 偽 and IL-IL-18 in each group were lower than those before treatment, and compared with those in western medicine group. Compared with the traditional Chinese medicine group and the western medicine group, the level of IL-18 in the western medicine group was significantly lower than that in the traditional Chinese medicine group and the western medicine group. Compared with the traditional Chinese medicine group and the western medicine group, the total clinical effective rate of the combined group was higher than that of the traditional Chinese medicine group and the western medicine group. The FBG level, UAER level and inflammatory factor level were significantly lower than those in the western medicine group, and compared with the western medicine group, the symptoms related to spleen qi deficiency (anorexia) in the combined group were significantly lower than those in the western medicine group. Conclusion: the combination of Tangshen recipe and beprostol sodium can improve the effect of reducing urine protein and improving inflammatory state in patients with lower urinary protein and lower inflammatory state, and no serious adverse reactions were found in the study of P0.050.Conclusion: the combination of Tangshen recipe and beprostol sodium can increase the level of urinary protein and improve the inflammatory state of the patients. It has good therapeutic effect on DKD in clinical stage.
【作者單位】： 上海中醫(yī)藥大學(xué)附屬第七人民醫(yī)院;
【基金】：上海市衛(wèi)生和計(jì)劃生育委員會(huì)中醫(yī)藥科研基金項(xiàng)目(2014LP032A);上海市衛(wèi)生和計(jì)劃生育委員會(huì)科研計(jì)劃項(xiàng)目(201440543) 上海市科學(xué)技術(shù)委員會(huì)科研計(jì)劃項(xiàng)目(15401930600)
【分類號(hào)】：R587.2;R692.9

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