本文選題：尿道狹窄　切入點(diǎn)：最大尿流率變化值　出處：《蘇州大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：1目的在尿道成形術(shù)術(shù)后，一種值得信賴的，對(duì)患者無(wú)創(chuàng)的篩查尿道再狹窄的方法是迫切需要的。我們推測(cè)術(shù)后尿流率與術(shù)前相比較（最大尿流率變化值），有可能幫助預(yù)測(cè)術(shù)后尿道狹窄復(fù)發(fā)。 2方法回顧性分析了本院從2012年3月到2013年11月間279名經(jīng)歷尿道重建手術(shù)男性患者資料。187名患者在術(shù)前和術(shù)后都對(duì)尿流率做了充分研究,并且所有患者行尿道造影金標(biāo)準(zhǔn)檢查，判別尿道狹窄情況。根據(jù)術(shù)后最大尿流率改變截點(diǎn)值繪制ROC曲線，分析最大尿流率變化值判別尿道狹窄方法的準(zhǔn)確性。 3結(jié)果在這個(gè)研究里，包含了總共279名男性患者接受尿道成形術(shù)，其中187名患者在術(shù)前和術(shù)后進(jìn)行了充分的尿流率檢測(cè)，尿道造影檢查研究。術(shù)前患者最大尿流率的平均值是11.2±0.8ml/s。131名無(wú)狹窄患者最大尿流率是18.6±11.3ml/s，與術(shù)前有顯著性統(tǒng)計(jì)學(xué)差異（p0.0001）。而56名狹窄患者最大尿流率是10.6±7.2ml/s,與術(shù)前無(wú)統(tǒng)計(jì)學(xué)差異（p=0.2630）。成功修復(fù)尿道的病人，，最大最大尿流率變化值平均值為19.2±11.7ml/s，對(duì)于不成功的修復(fù)尿道病人，最大最大尿流率變化值平均值為2.7±8.4ml/s,兩者相比,具有顯著性差異（p0.0001）。利用187名病人最大尿流率變化值的截點(diǎn)值繪制的ROC曲線顯示。作為尿道狹窄患者復(fù)發(fā)的篩選標(biāo)準(zhǔn)，當(dāng)最大尿流率變化值等于10ml/s時(shí)，能分別形成了92％靈敏度和78％的特異度。 4結(jié)論對(duì)于尿道狹窄病人，最大尿流率變化值檢測(cè)是一種有前途的篩查尿道再狹窄的方法，它具有無(wú)創(chuàng)性和高度敏感性。在尿道狹窄術(shù)后診斷再狹窄具有很高的應(yīng)用價(jià)值。
[Abstract]:Objective to provide a reliable method for urethroplasty. A noninvasive method for screening urethral restenosis is urgently needed. We speculate that the postoperative urinary flow rate is compared with that before operation (the maximum flow rate change value may help to predict the recurrence of postoperative urethral stricture.). Methods the data of 279 male patients undergoing urethral reconstruction from March 2012 to November 2013 were analyzed retrospectively. The ROC curve was drawn according to the change point of the maximum flow rate after operation, and the accuracy of the method of judging urethral stricture was analyzed by analyzing the change value of the maximum flow rate of urethra. Results in this study, a total of 279 male patients underwent urethroplasty, 187 of whom underwent adequate urine flow tests before and after surgery. Study on urethrography. The mean maximum flow rate was 11.2 鹵0.8 ml / s. 131 patients without stenosis, which was 18.6 鹵11.3 ml / s, which was significantly different from that before operation (p 0.0001), while the maximum flow rate in 56 patients with stenosis was 10.6 鹵7.2 ml / s, which was not statistically significant compared with that before operation. Patients with successful urethral repair, The mean value of the maximum flow rate was 19.2 鹵11.7ml / s, and for the unsuccessful urethral repair patients, the mean value of the maximum flow rate was 2.7 鹵8.4 ml / s. There was significant difference between the two groups (p 0.0001). The ROC curve was drawn using the cut-off point of the maximum uroflow rate change value in 187 patients. As a screening criterion for recurrence in urethral stricture patients, when the maximum uroflow rate change value was equal to 10 ml / s, The sensitivity of 92% and the specificity of 78% were obtained. Conclusion for urethral stricture patients, the detection of maximum flow rate is a promising screening method for urethral restenosis, which is noninvasive and highly sensitive, and has a high value in the diagnosis of restenosis after urethral stricture.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R695

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