本文關(guān)鍵詞： 腎移植 間充質(zhì)干細(xì)胞 急性排斥反應(yīng) 臍帶　出處：《福建醫(yī)科大學(xué)》2014年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的：觀察臍帶間充質(zhì)干細(xì)胞(hU-MSCs)輸注防治移植腎急性排斥反應(yīng)（AR）和促進(jìn)移植腎功能早期恢復(fù)中的有效性和安全性。方法：172例腎移植受者分為hU-MSCs組（121例）和對(duì)照組(51例)，hU-MSCs組于腎移植當(dāng)天和術(shù)后2周時(shí)分別經(jīng)外周靜脈輸注hU-MSCs，對(duì)照組不進(jìn)行任何誘導(dǎo)治療。觀察兩組AR的發(fā)生情況、移植腎功能、免疫抑制劑使用情況，隨訪時(shí)間為12個(gè)月。結(jié)果：兩組患者基本資料的差異無(wú)統(tǒng)計(jì)學(xué)意義(P＞0.05)。hU-MSCs組在術(shù)后AR的發(fā)生率分別為9.09％和15.69％，無(wú)統(tǒng)計(jì)學(xué)意義(P=0.208)。 hU-MSCs組術(shù)后7d的估算腎小球?yàn)V過(guò)率(eGFR)明顯高于對(duì)照組(P＜0.01)，兩組其他時(shí)間點(diǎn)eGFR的差異無(wú)統(tǒng)計(jì)學(xué)意義(P＞0.05)。術(shù)后應(yīng)用FK506劑量hU-MSCs組較對(duì)照組明顯減少，差異有統(tǒng)計(jì)學(xué)意義（P0.01）。而CsA的應(yīng)用劑量在術(shù)后2個(gè)月后hU-MSCs組明顯低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P0.05）。兩組移植后感染發(fā)生率的差異無(wú)統(tǒng)計(jì)學(xué)意義(P＞0.05)。hU-MSCs組術(shù)后肝功能異常的發(fā)生率為9.92%，低于對(duì)照組的41.18%(P＜0.001)。結(jié)論：術(shù)前hU-MSCs輸注可促進(jìn)移植腎功能早期恢復(fù)，，使用較低劑量的免疫抑制劑就能維持免疫抑制作用減少對(duì)肝臟的毒性且安全性較好。
[Abstract]:Objective: to observe the efficacy and safety of umbilical cord mesenchymal stem cells (hU-MSCs) infusion in the prevention and treatment of acute renal allograft rejection and the early recovery of renal function. Methods: 172 cases of renal transplantation recipients were divided into hU-MSCs group (n = 121) and control group (n = 121). 51 cases of hU-MSCs were injected with hU-MSCs via peripheral vein on the day of renal transplantation and 2 weeks after transplantation, while the control group did not undergo any induction therapy. The occurrence of AR in the two groups was observed. Graft function, use of immunosuppressants, Results: there was no significant difference in basic data between the two groups (P > 0.05). The incidence of AR in group A was 9.09% and 15.69, respectively. There was no significant difference in incidence of AR between two groups. The estimated glomerular filtration rate in hU-MSCs group was significantly higher than that in group hU-MSCs 7 days after operation. Compared with the control group (P < 0.01), there was no significant difference in eGFR between the two groups at other time points (P > 0.05). The postoperative FK506 dosage of hU-MSCs group was significantly lower than that of the control group. The dose of CsA in hU-MSCs group was significantly lower than that in control group 2 months after operation. There was no significant difference in the incidence of postoperative infection between the two groups (P > 0.05). The incidence of abnormal liver function in group A was 9.92, which was lower than that in group B (41.18% P < 0.001). Conclusion: preoperative infusion of hU-MSCs can promote the early recovery of renal transplantation. Lower doses of immunosuppressants can maintain immunosuppressive effects to reduce liver toxicity and are safe.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R699.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 林華欣;陳業(yè)輝;仉智;李淼沅;聶品;陳林強(qiáng);林武周;許進(jìn);杜洪;陳立中;邱江;陳國(guó)棟;謝克基;胡建波;鐘惟德;;腎移植術(shù)后首劑治療劑量環(huán)孢素A和他克莫司及雷帕霉素對(duì)獨(dú)腎大鼠肝臟功能的影響[J];廣東醫(yī)學(xué);2013年13期

2 卓鋒;魏開(kāi)斌;;人臍帶間充質(zhì)干細(xì)胞應(yīng)用研究進(jìn)展[J];中國(guó)矯形外科雜志;2012年01期

相關(guān)博士學(xué)位論文 前1條

1 馬濤;脂肪間充質(zhì)干細(xì)胞移植對(duì)大鼠小體積肝移植術(shù)后肝損傷的治療作用及機(jī)制研究[D];浙江大學(xué);2012年

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