本文關(guān)鍵詞： 利腎化濁湯 晚期腎癌 下焦?jié)駸嵝?臨床療效　出處：《湖南中醫(yī)藥大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：探討中藥利腎化濁湯聯(lián)合生物制劑治療下焦?jié)駸嵝屯砥谀I癌的臨床療效,為晚期腎癌的治療提供經(jīng)驗(yàn)。 方法：將入選的62例晚期腎癌患者隨機(jī)分為治療組和對(duì)照組,對(duì)照組采用生物制劑干擾素a和白細(xì)胞介素2治療方案。治療組在對(duì)照組生物治療的基礎(chǔ)上給予中藥利腎化濁湯內(nèi)服,6周為1個(gè)療程,1個(gè)療程后進(jìn)行療效判定。記錄并分析兩組患者治療前后臨床療效和生物制劑的毒副作用。 結(jié)果：治療1個(gè)療程后,(1)在瘤體大小方面治療組有效率為19.35%,對(duì)照組總有效率為16.13%,治療組較對(duì)照組有效率高,但無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)； (2)在中醫(yī)證候評(píng)分方面治療組優(yōu)于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)；在卡氏評(píng)分方面治療組優(yōu)于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)；在提高機(jī)體免疫功能方面,治療組在升高CD3+、CD4+值,降低CD8+值方面優(yōu)于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)；在減輕生物制劑的毒副反應(yīng)方面治療組優(yōu)于對(duì)照組,其差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論：在中醫(yī)理論指導(dǎo)下,在西醫(yī)常規(guī)治療基礎(chǔ)上辨證給予中藥利腎化濁湯治療下焦?jié)駸嵝屯砥谀I癌,可改善患者常見的臨床癥狀,提高患者Karnofsky評(píng)分,提高患者細(xì)胞免疫功能,減輕患者生物反應(yīng)調(diào)節(jié)劑治療導(dǎo)致的毒副反應(yīng)。
[Abstract]:Objective: To explore the clinical efficacy of Li Shen Hua Tong decoction combined with biologics in the treatment of late renal carcinoma of lower coke and heat type, and to provide experience for the treatment of advanced renal carcinoma.
Methods: a total of 62 patients with advanced renal cell carcinoma patients were randomly divided into treatment group and control group, the control group using biological agents a interferon and interleukin 2 therapy. The treatment group was given TCM kidney Huazhuo Decoction in the control group of biological treatment, 6 weeks for 1 courses, 1 courses to determine the efficacy analysis of two groups of patients before and after treatment. The clinical efficacy and side effects of biological agents and records.
Results: after 1 courses of treatment, (1) in the aspect of tumor size, the effective rate of the treatment group was 19.35%, while the total effective rate of the control group was 16.13%. The effective rate of the treatment group was higher than that of the control group, but it was not statistically significant (P0.05).
(2) the treatment group than the control group in TCM syndrome score, the difference was statistically significant (P0.05); the treatment group than the control group in the Karnofsky score, the difference was statistically significant (P0.05); in the aspect of improving the immune function in the treatment group, CD3+ increased, CD4 + value, reduce the value of CD8+ is better than the control group, the difference was statistically significant (P0.05); to reduce the toxicity of biological agents in the treatment group than the control group, the difference was statistically significant (P0.05).
Conclusion: under the guidance of TCM theory, on the basis of routine western medicine syndrome of damp heat type given the focus of advanced renal cell carcinoma of traditional Chinese medicine kidney Huazhuo decoction, can improve clinical symptoms of patients with common and improve the patients Karnofsky score, improve the cell immune function of the patients, reduce the toxicity associated with biological response modifier therapy.

【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R737.11

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

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本文編號(hào)：1516387