發(fā)布時間：2018-02-15 14:46

  本文關鍵詞： 泛素-蛋白酶體系統(tǒng) 精子DNA 損傷修復 男性不育　出處：《中華男科學雜志》2016年09期 　論文類型：期刊論文

【摘要】：泛素-蛋白酶體系統(tǒng)(UPS)是體內(nèi)廣泛存在的一種蛋白酶體系統(tǒng),由泛素(Ub)、泛素激活酶(E1)、泛素結合酶(E2)、泛素連接酶(E3)、26S蛋白酶體和去泛素化酶(DUBs)組成,能夠調(diào)控體內(nèi)蛋白降解。研究發(fā)現(xiàn)UPS除了蛋白降解功能以外,還參與細胞周期調(diào)控、免疫應答、信號傳導以及DNA損傷修復等過程。精子發(fā)生要經(jīng)歷染色體聯(lián)會、同源重組等過程,精子DNA在這些過程中易受干擾而出現(xiàn)損傷。近年來研究發(fā)現(xiàn),UPS與精子發(fā)生當中的DNA損傷修復有關。UPS參與DNA損傷的修復機制包括:泛素化調(diào)節(jié)DNA損傷修復相關酶類、協(xié)助識別DNA損傷位點、募集損傷修復相關蛋白、啟動DNA損傷修復途徑、維持染色體穩(wěn)定,從而保證精子發(fā)生正常進行。
[Abstract]:Ubiquitin proteasome system (UPSs) is a kind of proteasome system, which is composed of ubiquitin (UbN), ubiquitin activator (Ub1), ubiquitin binding enzyme (Ub1), ubiquitin binding enzyme (UTP), ubiquitin ligase (E3) and diubiquitin (DUBs). In addition to protein degradation, UPS is involved in cell cycle regulation, immune response, signal transduction and DNA damage repair. Homologous recombination and other processes, In recent years, it has been found that DNA is involved in the repair of DNA damage during spermatogenesis. The mechanisms involved in the repair of DNA damage include ubiquitin regulation of DNA damage repair related enzymes. Help to identify DNA damage sites, recruit damage repair related proteins, initiate DNA damage repair pathway, maintain chromosome stability, so as to ensure normal spermatogenesis.
【作者單位】： 南方醫(yī)科大學附屬金陵醫(yī)院/南京軍區(qū)南京總醫(yī)院男科;
【分類號】：R698.2

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