本文關(guān)鍵詞： 腎康注射液 老年患者 造影劑腎病　出處：《中國中西醫(yī)結(jié)合雜志》2016年07期 　論文類型：期刊論文

【摘要】：目的探討中藥制劑腎康注射液對老年慢性腎病患者造影劑腎病(contrast-induced nephropathy,CIN)防治的安全性和有效性。方法將206例老年慢性腎病擬行冠狀動脈造影的患者按照隨機數(shù)字表法分為水化組(67例)、腎康組(71例)和對照組(68例)。水化組手術(shù)前后12 h,均予0.9%氯化鈉注射液靜脈滴注。腎康組予腎康注射液靜脈滴注,對照組予靜脈滴注5%葡萄糖,兩組均術(shù)前3天及術(shù)后應(yīng)用4天,每天1次。觀察各組患者CIN的發(fā)生率,以及術(shù)前、術(shù)后24、96 h肌酐、尿素氮、血清胱抑素C(serum cystatin C,Cys C)、腎損傷分子-1(kidney injury molecule-1,KIM-1)和β2-微球蛋白(β2-microglobulin,β2-MG)腎功能指標(biāo)改變。通過Sperman相關(guān)性分析,比較年齡、性別、腎康注射液、造影劑用量、術(shù)前腎功能指標(biāo)水平與24 h肌酐變化值(術(shù)后24 h-術(shù)前)、CIN發(fā)生率的相關(guān)性,并進行Logistic回歸分析。結(jié)果與水化組及對照組比較,腎康組患者CIN發(fā)病率明顯降低,差異有統(tǒng)計學(xué)意義(χ2=5.32,P0.05)。與本組治療前比較,治療24、96 h后3組患者肌酐和Cys C水平均升高(P0.05),水化組和對照組KIM-1升高(P0.05),腎康組β2-MG水平升高(P0.05);與對照組比較,腎康組術(shù)后24 hβ2-MG升高(P0.05),其他指標(biāo)組間比較,差異均無統(tǒng)計學(xué)意義(P0.05)。腎康治療與CIN發(fā)生率和24 h肌酐變化呈負相關(guān)(r=-0.612、-0.517,P0.05)。造影劑用量與CIN發(fā)生率和24 h肌酐變化呈正相關(guān)(r=0.644、0.562,P0.05)。造影劑用量增加使CIN發(fā)生率升高(P0.05),腎康治療后CIN發(fā)生率明顯降低(P0.05)。結(jié)論中藥制劑腎康注射液對老年腎功能不全患者CIN起到一定的防治作用,降低CIN的發(fā)生率。
[Abstract]:Objective to investigate the traditional Chinese medicine preparation Shenkang injection of contrast agent nephropathy in elderly patients with chronic kidney disease (contrast-induced nephropathy, CIN) the safety and effectiveness of prevention and treatment. Methods 206 cases of elderly patients with chronic kidney disease undergoing coronary angiography were randomly divided into hydration group (67 cases), Shenkang group (71 cases) and control group (68 cases). The hydration group before and after the operation of 12 h, 0.9% were treated by intravenous drip. The Sodium Chloride Injection group, Shenkang Shenkang injection intravenous infusion, the control group received intravenous infusion of 5% glucose, two groups were 3 days before and after operation, 4 days, 1 times per day. To observe the incidence of CIN, and preoperative, postoperative 24,96 h creatinine, urea nitrogen, serum cystatin C (serum cystatin C, Cys C), -1 (kidney injury kidney injury molecule molecule-1, KIM-1) and beta 2- microglobulin (beta 2-microglobulin and beta 2-MG) renal function index changes by Sperman. Correlation 鏋，

本文編號：1497445