本文關(guān)鍵詞： 良性前列腺增生癥 中西藥聯(lián)合 優(yōu)化方案　出處：《黑龍江中醫(yī)藥大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：通過比較癃閉舒膠囊聯(lián)合甲磺酸多沙唑嗪、單純癃閉舒膠囊、單純甲磺酸多沙唑嗪治療良性前列腺增生癥(BPH)的臨床療效,探索中西藥聯(lián)合治療本病的作用機理,以優(yōu)化BPH的臨床治療方案。 方法：90例受試者均來自黑龍江中醫(yī)藥大學(xué)附屬第二醫(yī)院男科門診。經(jīng)詢問病史、B超檢查、直腸指檢、尿流率測定等檢查確診為良性前列腺增生癥的患者。用SPSS軟件產(chǎn)生的隨機數(shù)字表,進行入組病例的分配。隨機分為A、B、C三個組別,每組各30例。A組(對照I組)甲磺酸多沙唑嗪和癃閉舒膠囊安慰劑；B組(治療組)甲磺酸多沙唑嗪聯(lián)合癃閉舒膠囊；C組(對照II組)甲磺酸多沙唑嗪安慰劑和癃閉舒膠囊。甲磺酸多沙唑嗪(每次0.9g,每日2次),癃閉舒膠囊(每次2mg,每日一次),安慰劑用法同原藥。治療后對臨床癥狀、IPSS、最大尿流率、殘余尿量、前列腺體積等指標進行對照分析。 結(jié)果：1.本研究共入選90例患者,脫落和剔除病例18例,最后有效病例72例。其中A組23例,B組23例,C組26例。A組總有效為86.96%；B組總有效91.30%；C組總有效率為76.92%。2.三組治療前后的國際前列腺評分表(IPSS)、中醫(yī)癥狀評分、最大尿流率(Qmax)、生活質(zhì)量評分(Q01)均有明顯改善,有統(tǒng)計學(xué)意義(P0.05)。3.前列腺體積(PV)和殘余尿量(RU)治療前后無明顯改善,差異無統(tǒng)計學(xué)意義(P0.05)。 結(jié)論：1.癃閉舒膠囊聯(lián)合甲磺酸多沙唑嗪可顯著降低BPH患者的國際前列腺評分(IPSS),明顯改善BPH患者的排尿困難、夜尿頻多、尿線變細和少腹脹痛等臨床癥狀。2.癃閉舒膠囊聯(lián)合甲磺酸多沙唑嗪可以明顯提高BPH患者的最大尿流率和生活質(zhì)量。3.三組治療方案在減少殘余尿量、縮小前列腺體積方面療效均不明顯。4.三組治療方案在研究過程中均未出現(xiàn)明顯不良反應(yīng)。
[Abstract]:Objective: to compare the clinical effects of Longbishu capsule combined with doxazosin mesylate, Longbishu capsule alone and doxazosin mesylate alone in the treatment of benign prostatic hyperplasia (BPH). To explore the mechanism of combined Chinese and western medicine for the treatment of this disease in order to optimize the clinical treatment of BPH. Methods 90 subjects were collected from Department of andrology, second affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. The patients diagnosed as benign prostatic hyperplasia (BPH) were divided into three groups randomly by SPSS software. Each group consisted of 30 patients in group A (control group I) and placebo in doxazosin mesylate and Longbushu capsules. Group B (treatment group): doxazosin mesylate combined with Longbishu capsule; Group C (control group II): doxazosin mesylate placebo and longbast capsule. Doxazosin mesylate (0.9g / d, twice daily), Longbishu capsule (2mg / day). After treatment, the clinical symptoms of IPSS, maximum flow rate, residual urine volume, prostate volume and so on were compared and analyzed. Results 1. In this study, 90 patients were selected, 18 cases were dropped off and 18 cases were excluded, and 72 cases were effective, 23 cases were in Group A and 23 cases were in Group B. The total effective rate of group C (26 cases) was 86.96; The total effective rate of group B was 91.30%; The total effective rate of group C was 76.92. The international prostate scoring scale before and after treatment was IPSS, TCM symptom score, maximum urinary flow rate (Qmax.). Q01), there was no significant improvement before and after treatment (P 0.05) and residual urine volume (RUU) before and after treatment. The difference was not statistically significant (P 0.05). Conclusion 1. Longbishu capsule combined with doxazosin mesylate can significantly reduce the international prostatic score of BPH patients and improve the dysuria of BPH patients with more frequent nocturnal urination. Longbeshu capsule combined with doxazosin mesylate can significantly improve the maximum urinary flow rate and quality of life of patients with BPH .3.The three treatment groups in reducing residual urine volume. The effect of reducing prostate volume was not obvious. 4. No significant adverse reactions were observed in the three treatment groups in the course of the study.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R697.3

【參考文獻】

相關(guān)期刊論文 前10條

1 李東;;王琦教授治療良性前列腺增生的經(jīng)驗[J];中華中醫(yī)藥雜志;2011年02期

2 劉學(xué);崔健;陳新;;廣金錢草現(xiàn)代研究進展[J];長春中醫(yī)藥大學(xué)學(xué)報;2006年04期

3 沈敏娟;左進;王文春;;王文春主任醫(yī)師治療前列腺增生經(jīng)驗介紹[J];甘肅中醫(yī);2006年06期

4 寫國斌;何光榮;錢文年;任培虎;曾志秀;;自制啟閉安藥物鞋墊配合靶向超聲中藥導(dǎo)入治療慢性前列腺增生的臨床觀察[J];甘肅中醫(yī);2011年05期

5 張德麗;王平軍;;中藥直腸灌注療法治療良性前列腺增生癥56例[J];光明中醫(yī);2013年12期

6 周樹軍;馬利民;李華鐳;張躍平;;良性前列腺增生癥合并組織學(xué)前列腺炎臨床分析[J];交通醫(yī)學(xué);2010年04期

7 楊勇;;從循證醫(yī)學(xué)證據(jù)理解良性前列腺增生的藥物治療[J];臨床藥物治療雜志;2007年02期

8 王建龍;朱剛;萬奔;;愛普列特在治療良性前列腺增生中的應(yīng)用[J];現(xiàn)代泌尿外科雜志;2006年04期

9 洪振豐;;良性前列腺增生實驗研究的選擇指標[J];中華男科學(xué)雜志;2008年09期

10 張敏道;趙勇寧;安立文;;Bcl-2基因與良性前列腺增生[J];中華男科學(xué)雜志;2009年05期

相關(guān)博士學(xué)位論文 前1條

1 何樂業(yè);前列腺增生癥與下尿路癥狀的臨床研究[D];中南大學(xué);2010年

，

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