本文關(guān)鍵詞： 紅細(xì)胞分布寬度 促紅細(xì)胞生成素抵抗 血液透析 橫斷面研究　出處：《免疫學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的了解維持性血液透析患者紅細(xì)胞分布寬度(red blood cell distribution width,RDW)與促紅細(xì)胞生成素抵抗的相關(guān)性。方法在2015年3月至2016年3月新橋醫(yī)院血液透析中心行維持性透析及重組人促紅細(xì)胞生成素治療≥6個(gè)月660例患者中篩選出資料完整的253例(根據(jù)每周rhu EPO治療劑量分為3亞組:A組,rhu EPO治療劑量150 IU·kg~(-1)·week~(-1),共有82例患者;B組,150 IU·kg~(-1)·week~(-1)≤rhu EPO治療劑量300 IU·kg~(-1)·week~(-1),共有137例患者;C組,rhuEPO治療劑量≥300 IU·kg~(-1)·week~(-1),共34例患者)進(jìn)行回顧性分析,考察RDW與促紅細(xì)胞生成素抵抗指數(shù)(erythropoietin resistance index,ERI)的相關(guān)性;同時(shí)選取健康成人200例,比較2組RDW的差異。結(jié)果秩和檢驗(yàn)提示血透組RDW顯著高于健康對(duì)照組(P0.05),不同rhu EPO治療劑量組血液透析患者中RDW、ERI有顯著差異。Person分析結(jié)果顯示:ERI與血紅蛋白(r=-0.434,P0.000 1)、血清鐵(r=-0.168,P=0.008)呈負(fù)相關(guān);與RDW(r=0.294,P0.000 1)、透析月齡(r=0.180,P=0.004)、ln CRP(r=0.200,P=0.001)呈正相關(guān)。多元線性回歸顯示:血紅蛋白、RDW與ERI顯著相關(guān)。結(jié)論在血透患者中,RDW與ERI獨(dú)立相關(guān),對(duì)于促紅細(xì)胞生成素抵抗的判斷、指導(dǎo)rhu EPO的臨床應(yīng)用,具有重要參考價(jià)值。
[Abstract]:Objective to investigate the red blood cell distribution width in maintenance hemodialysis patients. RDW). Methods maintenance dialysis and recombinant human erythropoietin therapy were performed in the hemodialysis center of Xinqiao Hospital from March 2015 to March 2016. 253 patients with complete data were screened out (. According to the weekly dose of rhu EPO, they were divided into 3 subgroups: group A. The dosage of rhu EPO was 150 IU 路kg ~ (-1) 路week ~ (-1). There were 82 patients. Group B (150IU 路kg-1) 路week-1) 鈮，

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