本文關(guān)鍵詞： 尿毒癥 血液透析 免疫指標(biāo) 血清炎性因子　出處：《現(xiàn)代免疫學(xué)》2017年06期 　論文類型：期刊論文

【摘要】：探究尿毒癥血液透析患者透析前后免疫指標(biāo)及IL-6、CRP、IL-8、TNF-α的變化。抽取2013年4月至2015年10月我院78例尿毒癥患者,隨機(jī)數(shù)表法分組,各39例。實(shí)驗(yàn)組采用高通量血液透析(high-flux hemodialysis,HFHD),對(duì)照組采用低通量血液透析(low-flux hemodialysis,LFHD),兩組均觀察治療6個(gè)月。對(duì)比治療前后兩組免疫指標(biāo)CIgA、IgG、IgM及其C3、C4)、紅細(xì)胞免疫指標(biāo)[紅細(xì)胞免疫復(fù)合花環(huán)(erythrocyte immune complex rosette,RBC-ICR)、紅細(xì)胞免疫抑制率(erythrocyte immunosuppressive rate,RFIR)、紅細(xì)胞C3b受體(erythrocyte C3breceptor,RBC-C3bR)、紅細(xì)胞免疫促進(jìn)因子(erythrocyte immune promoting factor,RFER)]、血清炎性因子(IL-6、IL-8、CRP、TNF-α)及營養(yǎng)狀態(tài)指標(biāo)(PA、ALB、Hb)水平變化情況。(1)免疫指標(biāo):治療后兩組IgA、IgG、IgM、C3、C4等指標(biāo)水平均較治療前增高,且實(shí)驗(yàn)組IgA、IgG、IgM、C3、C4水平高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);(2)紅細(xì)胞免疫指標(biāo):治療后實(shí)驗(yàn)組RBC-ICR、RFIR水平低于對(duì)照組,RBC-C3bR、RFER水平高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);(3)血清炎性因子:治療后兩組IL-6、IL-8、TNF-α、CRP等指標(biāo)水平均較治療前降低,且實(shí)驗(yàn)組各指標(biāo)低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);(4)營養(yǎng)狀態(tài):治療后兩組各指標(biāo)水平均較治療前增高,且實(shí)驗(yàn)組PA、ALB、Hb水平高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。采用血液透析治療尿毒癥患者可有效降低血清炎性因子水平,改善免疫功能及營養(yǎng)狀態(tài),且HFHD效果優(yōu)于LFHD。
[Abstract]:Objective: to investigate the immune index and IL-6 CRP IL-8 in patients with uremia before and after hemodialysis. The changes of TNF- 偽. From April 2013 to October 2015, 78 patients with uremia in our hospital were randomly divided into two groups. The experimental group was treated with high-flux hemodialysis high-flux hemodialysis (HFHD). The control group was treated with low-flux hemodialysis and low-flux hemodialysis for 6 months. The immune index CIgA was compared before and after treatment. IgGN IgM and its C _ 3C _ 4C _ (4), erythrocyte immune Indexes. [Erythrocyte immune complex rosette (RBC-ICR). Erythrocyte immunosuppressive rate and erythrocyte immunosuppressive rateir). Erythrocyte C3b receptor RBC-C3bR. Erythrocyte immune promoting factor (RFER) and serum inflammatory factor IL-6 (IL-8). The changes of the level of CRPnTNF- 偽 and the nutritional status index (PAA) ALB (Hb): after treatment, the two groups were immunized with IgA, IgG, IgM, C 3. The level of C4 was higher than that before treatment, and the level of IgAg C _ 3C _ 3C _ 4 in the experimental group was higher than that in the control group (P < 0.05). (2) erythrocyte immune index: the RFIR level of RBC-ICRN in the experimental group was lower than that in the control group after treatment, and the level of rfer was higher than that in the control group. The difference was statistically significant (P 0.05). 3) Serum inflammatory factors: after treatment, the levels of IL-6, IL-8, TNF- 偽 and CRP in the two groups were lower than those before treatment, and the indexes in the experimental group were lower than those in the control group. The difference was statistically significant (P 0.05). (4) nutritional status: after treatment, the level of each index in the two groups was higher than that before treatment, and the level of PABBU HB in the experimental group was higher than that in the control group. The difference was statistically significant (P 0.05). Hemodialysis could effectively reduce the level of serum inflammatory factors, improve the immune function and nutritional status, and the effect of HFHD was better than that of LFHD.
【作者單位】： 河北醫(yī)科大學(xué)第一醫(yī)院腎內(nèi)科;
【基金】：河北省衛(wèi)生廳醫(yī)學(xué)科學(xué)研究課題(20120298)
【分類號(hào)】：R692.5
【正文快照】： 現(xiàn)代醫(yī)學(xué)認(rèn)為尿毒癥為患者喪失腎功能后,機(jī)體生化過程紊亂而出現(xiàn)的一系列復(fù)雜綜合征,其本質(zhì)是機(jī)體無法經(jīng)腎臟產(chǎn)生尿液,進(jìn)而將機(jī)體中代謝廢物與過多水分排出體外,從而引發(fā)毒害[1-2]。血液透析(hemodialysis,HD)為臨床救治尿毒癥患者的主要措施,可取得一定療效,但尿毒癥持續(xù)HD患

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 葉峰;鄭劍峰;沈科;胡堅(jiān)鋒;余文華;;腦脊液TNF在兒童中樞神經(jīng)系統(tǒng)感染的臨床意義[J];浙江臨床醫(yī)學(xué);2007年12期

2 金艷艷,胡堅(jiān);抗TNF-α治療的最新研究進(jìn)展[J];細(xì)胞與分子免疫學(xué)雜志;2005年S1期

3 王新，許才紱，趙國寧，陳岳祥，王慶莉，，楊琨，金伯泉;慢性肝病患者血清腫瘤壞死因子-a與IL-8的檢測[J];中華微生物學(xué)和免疫學(xué)雜志;1995年01期

4 時(shí)彥;外周血單個(gè)核細(xì)胞產(chǎn)生IL-8影響因素的探討[J];南京鐵道醫(yī)學(xué)院學(xué)報(bào);1997年03期

5 毛曉群;張海嫦;翁雪玲;;TNF-α拮抗劑治療難治性復(fù)發(fā)性多軟骨炎的護(hù)理[J];當(dāng)代護(hù)士(中旬刊);2013年06期

6 季明春;;健康人、風(fēng)濕病患者及革蘭氏陰性細(xì)菌感染患者血清TNF α自身抗體[J];國外醫(yī)學(xué)(微生物學(xué)分冊(cè));1990年04期

7 王長青;;新生兒缺氧缺血性腦病中TNF-α變化的研究[J];中國婦幼保健;2010年04期

8 王迪;姜莉;;慢性阻塞性肺疾病患者血清sFas與TNF-α水平的檢測和意義[J];中國實(shí)用醫(yī)藥;2010年04期

9 于蘭,陳新民,高福興,靳彩寧,許建明;腫瘤患者外周血單個(gè)核細(xì)胞培養(yǎng)上清TNF-α含量測定[J];上海免疫學(xué)雜志;1997年03期

10 葛偉國,許以平,姚蘇杭,曹玲仙,王茂;患哮喘產(chǎn)婦的新生兒臍血IL-8測定[J];標(biāo)記免疫分析與臨床;2000年03期

相關(guān)會(huì)議論文 前1條

1 劉獻(xiàn)祥;;毫米波抑制TNF-α誘導(dǎo)NF-κB信號(hào)轉(zhuǎn)導(dǎo)通路的實(shí)驗(yàn)研究[A];2010中國醫(yī)師協(xié)會(huì)中西醫(yī)結(jié)合醫(yī)師大會(huì)摘要集[C];2010年

相關(guān)碩士學(xué)位論文 前3條

1 荊治;攜IL-8單克隆抗體靶向性聲學(xué)造影劑對(duì)兔腹主動(dòng)脈粥樣斑塊的實(shí)驗(yàn)研究[D];昆明醫(yī)科大學(xué);2012年

2 段吉明;內(nèi)毒素干預(yù)離體大鼠淋巴細(xì)胞后TLR4、NF-κB、TNF-α及IL-6的體外研究[D];山西醫(yī)科大學(xué);2014年

3 王安平;肺結(jié)核患者外周血及支氣管肺泡灌洗液中IL-6及IL-8測定的臨床意義[D];安徽醫(yī)科大學(xué);2002年

本文編號(hào)：1480691