重比重與等比重布比卡因蛛網(wǎng)膜下腔阻滯麻醉對(duì)Narcotrend引導(dǎo)右美托咪定鎮(zhèn)靜效果的影響
發(fā)布時(shí)間:2018-11-18 06:30
【摘要】:目的比較重比重與等比重布比卡因蛛網(wǎng)膜下腔阻滯麻醉對(duì)Narcotrend引導(dǎo)右美托咪定(Dex)鎮(zhèn)靜效果的影響。方法選擇2012年11月—2013年5月在婦科擇期行開腹子宮全切除術(shù)的患者48例,美國(guó)麻醉醫(yī)師協(xié)會(huì)分級(jí)Ⅰ或Ⅱ級(jí),隨機(jī)分入重比重布比卡因蛛網(wǎng)膜下腔阻滯麻醉組(重比重組,10%葡萄糖溶液1mL+0.75%布比卡因2mL)和等比重布比卡因蛛網(wǎng)膜下腔阻滯麻醉組(等比重組,0.75%布比卡因2mL+腦脊液1mL),每組24例。調(diào)整藥物注射速度以控制無(wú)痛平面為T6至T8。平均動(dòng)脈壓(MAP)下降基礎(chǔ)值的30%時(shí)予靜脈注射麻黃素6mg,心率下降至50次/min時(shí)予靜脈注射阿托品0.5mg。兩組均在阻滯平面固定后,靜脈注射Dex負(fù)荷劑量0.5μg/kg,之后以0.6μg·kg~(-1)·h~(-1)持續(xù)泵入。術(shù)中每次上調(diào)或下調(diào)Dex泵入量0.2μg·kg~(-1)·h~(-1),以維持Narcotrend指數(shù)為70~80。記錄患者的Dex初始用量(鎮(zhèn)靜開始至Narcotrend指數(shù)為70時(shí)的Dex劑量)和總用藥量。分別于入手術(shù)室時(shí)、手術(shù)切皮、牽拉腹腔時(shí)、手術(shù)結(jié)束時(shí)各時(shí)間點(diǎn),記錄患者的心率、呼吸頻率、MAP和脈搏血氧飽和度(S_pO_2)。記錄患者的手術(shù)時(shí)間和鎮(zhèn)靜時(shí)間。記錄使用麻黃素和阿托品的患者比例,以及輸液量和出血量。結(jié)果兩組間手術(shù)時(shí)間、鎮(zhèn)靜時(shí)間、Dex初始用量、使用麻黃素和阿托品的患者比例、輸液量、出血量的差異均無(wú)統(tǒng)計(jì)學(xué)意義(Ρ值均0.05),重比重組Dex總用量顯著少于等比重組(P0.05)。兩組間患者圍術(shù)期各時(shí)間點(diǎn)的心率、呼吸頻率、MAP和S_pO_2的差異均無(wú)統(tǒng)計(jì)學(xué)意義(Ρ值均0.05)。結(jié)論與等比重布比卡因相比,重比重布比卡因蛛網(wǎng)膜下腔阻滯麻醉可減少Narcotrend引導(dǎo)Dex鎮(zhèn)靜時(shí)Dex的總用量,但不能減少Dex的初始用量。
[Abstract]:Objective to compare the effects of heavy specific gravity bupivacaine subarachnoid block anesthesia on the sedation effect of dexmetidine (Dex) guided by Narcotrend. Methods from November 2012 to May 2013, 48 patients undergoing open hysterectomy in gynecological department were randomly divided into two groups (weight ratio recombination), which were classified as grade 鈪,
本文編號(hào):2339152
[Abstract]:Objective to compare the effects of heavy specific gravity bupivacaine subarachnoid block anesthesia on the sedation effect of dexmetidine (Dex) guided by Narcotrend. Methods from November 2012 to May 2013, 48 patients undergoing open hysterectomy in gynecological department were randomly divided into two groups (weight ratio recombination), which were classified as grade 鈪,
本文編號(hào):2339152
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