發(fā)布時間：2018-09-17 07:35

【摘要】：目的探討SCN9A基因多態(tài)性與婦科腹腔鏡手術(shù)患者羅哌卡因局部浸潤鎮(zhèn)痛效果的相關(guān)性。方法選擇擇期行婦科腹腔鏡手術(shù)患者200例,采用隨機、對照和雙盲的研究方法將患者分為兩組,分別在手術(shù)切皮前5min在切口部位局部浸潤0.75%羅哌卡因12ml(R組)和等量生理鹽水(C組),術(shù)中均采用TCI丙泊酚血漿靶濃度3μg/ml,瑞芬太尼血漿靶濃度3ng/ml,吸入七氟醚維持麻醉。CO2氣腹壓維持在≤12mm Hg。記錄術(shù)后切口部位VAS疼痛評分。抽取外周靜脈血2ml提取DNA,應(yīng)用PCR技術(shù)結(jié)合DNA直接測序方法分析患者SCN9A基因型。結(jié)果 SCN9A基因第15號外顯子2794(A/C)基因突變與術(shù)后疼痛無明顯相關(guān);SCN9A基因第18號外顯子3448(C/T)基因突變與術(shù)后疼痛存在相關(guān)性(P0.05)。結(jié)論 SCN9A基因第18號外顯子3448(C/T)的雜合突變與術(shù)后疼痛的發(fā)生具有相關(guān)性,但對羅哌卡因的疼痛效果無明顯影響。
[Abstract]:Objective to investigate the relationship between SCN9A gene polymorphism and ropivacaine local invasive analgesia in gynecological laparoscopic surgery. Methods 200 patients undergoing gynecological laparoscopic surgery were divided into two groups by randomized, controlled and double-blind study. Before skin incision, 5min infiltrated 0.75% ropivacaine 12ml (group R) and saline (group C). TCI propofol plasma target concentration was 3 渭 g / ml, remifentanil plasma target concentration was 3 ng / ml, sevoflurane was inhaled to maintain anesthesia. CO2 pneumoperitoneum pressure maintained at 鈮，

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