本文選題：高糖飲食 + 非酒精性脂肪肝�。� 參考：《時珍國醫(yī)國藥》2017年01期

【摘要】：目的比較過食肥甘、過食肥甘同時過逸,導致生痰致瘀、痰瘀互結(jié),而發(fā)肝癖的特點,為臨床基于甘滿生痰防治肝癖的思路提供參考。方法以高糖飼料飼養(yǎng)模擬過食肥甘、致痰濕內(nèi)生、痰瘀互結(jié)而生肝癖;以丙基硫氧嘧啶(PTU)抑制代謝率、減少消耗模擬過逸。觀察其對血脂、肝臟脂肪變的影響,以探討甘滿生痰對肝癖的致病機制,為飲食防治非酒精性脂肪肝(NAFLD)提供依據(jù)。方法正常雄性SD大鼠30只,按體重隨機分成高糖1組、高糖2組和對照組。高糖1組飼以高糖低代謝飼料,高糖2組飼以高糖飼料,對照組飼以正常飼料。16周后,禁食不禁水12h,麻醉后取血清檢測肝功能、血脂,取肝臟組織進行油紅O及HE染色。結(jié)果甘油三酯(TG):高糖2組高于其他兩組,膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C):高糖1組高于其他兩組,谷丙轉(zhuǎn)氨酶(ALT):高糖1組明顯高于其他兩組,谷草轉(zhuǎn)氨酶(AST)、γ-谷氨酰轉(zhuǎn)移酶(γ-GT):高糖1組高于其他兩組,脂肪肝程度:高糖兩組均有脂肪變性,2組較1組嚴重,對照組為陰性。結(jié)論高糖飲食能導致肝臟一定程度的脂肪變性,并能導致血脂、肝功能異常;過食肥甘是釀成痰濕、郁久化瘀、痰瘀互結(jié)損傷肝臟而致肝癖的重要原因。
[Abstract]:Objective to compare the characteristics of febrile Gan and excessive fatness at the same time, resulting in phlegm and blood stasis, and to provide a reference for clinical treatment of liver fetid based on Ganmansheng phlegm. Methods the rats were fed with high sugar diet to induce phlegm dampness endogenesis phlegm and blood stasis to produce liver fetid while propyl thiouracil (PTU) inhibited metabolic rate and reduced consumption of simulated excessive escape. In order to explore the pathogenic mechanism of Ganmansheng phlegm on lipids and liver steatosis, it can provide basis for diet prevention and treatment of non-alcoholic fatty liver (NAFLD). Methods 30 normal male SD rats were randomly divided into three groups according to their body weight: high glucose group, high glucose group 2 and control group. Group 1 was fed with high sugar and low metabolism diet, group 2 with high sugar and control group with normal diet for 16 weeks. After fasting for 12 hours, serum samples were taken to detect liver function, blood lipid and liver tissues for oil red O and HE staining. Results triglyceride (TG): high glucose group 2 was higher than the other two groups, cholesterol (TC), low density lipoprotein cholesterol (LDL-C): high glucose group 1 was higher than the other two groups, alt: high glucose group 1 was significantly higher than the other two groups. Aspartate aminotransferase (AST), 緯 -glutamyl transferase (緯 -GT): high glucose group 1 was higher than the other two groups, fatty liver degree: the fatty liver degree of both groups were more serious than that of the first group, but the control group was negative. Conclusion High glucose diet can lead to a certain degree of fatty degeneration of liver, and lead to abnormal blood lipid and liver function, too much fat and sweet food is an important cause of liver damage caused by phlegm dampness, depression and blood stasis, phlegm and blood stasis.
【作者單位】： 福建中醫(yī)藥大學;福建中醫(yī)藥大學附屬人民醫(yī)院;
【基金】：國家自然科學基金(No.81173179;No.81473550;No.81403329) 福建省科技社會發(fā)展重點項目(No.2012Y0037) 福建省衛(wèi)生廳中醫(yī)藥科研重點研究室基金(No.wztn 201304) 福建中醫(yī)藥大學重點學科專項基金(No.X2014037)
【分類號】：R285.5

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