本文選題：瑞芬太尼 + 痛覺過敏　； 參考：《中國新藥雜志》2015年24期

【摘要】：目的:瑞芬太尼(RF)誘發(fā)的阿片源性痛覺過敏抑制了其在臨床麻醉的使用。脊髓星形膠質(zhì)細胞的活化可能與其相關。本實驗探討RF誘發(fā)痛覺過敏與星形膠質(zhì)細胞活化的關系,同時研究電針治療是否從機制上抑制痛敏的發(fā)生。方法:SD大鼠72只隨機分為4組,每組均作切口痛模型:I組(切口痛對照組)尾靜脈泵注生理鹽水;R+I組(RF痛敏組)尾靜脈泵注RF 0.8μg·kg-1;R+T組(電針治療組)泵注RF前30 min開始電針治療直至術畢;R+F組(假治療組):泵注RF前以穴位電針刺激直至術畢。分別在術前24 h、RF輸注后4,12,24和48 h測量各實驗組大鼠的熱刺激縮足潛伏期(PWTL)和機械刺激縮足閾(PWMT)。按不同時間點(4,24和48 h)處死實驗大鼠,并取腰段脊髓測GFAP的濃度。結果:1行為學指標:RF痛敏組機械痛閾與熱痛閾均高于切口痛對照組(P0.05),電針治療組低于RF痛敏組(P0.05)。2標本GFAP表達:RF痛敏組明顯高于切口痛對照組(P0.05),電針治療組低于RF痛敏組(P0.05)。結論:實驗證實了脊髓星形膠質(zhì)細胞活化與瑞芬太尼誘導的痛覺過敏密切相關,電針治療可以抑制其活化,從而預防瑞芬太尼導致的痛覺過敏,給臨床的多模式鎮(zhèn)痛提供理論依據(jù)。
[Abstract]:Objective: remifentanil (RF)-induced opioid hyperalgesia inhibits the use of anaesthesia. The activation of spinal astrocytes may be associated with it. This study was to investigate the relationship between RF induced hyperalgesia and astrocyte activation. Methods 72 Sprague-Dawley rats were randomly divided into 4 groups. Each group was given incision pain model: 1: 1 group (incision pain control group), caudal vein pump injection of normal saline Ri group (RF pain sensitive group) caudal vein pump injection RF 0.8 渭 g kg ~ (-1) R T group (electroacupuncture group) 30 min before pump injection of RF acupuncture treatment until the end of surgery R F Group (sham treatment group): before pump RF injection, acupoint electroacupuncture was used until the end of operation. The latent period of thermal stimulation (PWTL) and mechanical stimulation of foot contraction threshold (PWMT) were measured 24 and 48 hours after RF infusion at 24 hours before operation in each experimental group. The experimental rats were killed at different time points (4 h and 48 h), and the concentration of GFAP in lumbar spinal cord was measured. Results the mechanical pain threshold and thermal pain threshold of the 1: 1 behavioral index group were higher than those of the incision pain control group (P0.05), and the GFAP expression of GFAP in the electroacupuncture group was significantly higher than that in the incision pain control group (P0.05), and the expression of GFAP in the electroacupuncture group was significantly higher than that in the incision pain control group (P0.05), and that in the electroacupuncture group was lower than that in the RF pain sensitive group (P0.05). Conclusion: activation of astrocytes in spinal cord is closely related to remifentanil induced hyperalgesia. Electroacupuncture can inhibit the activation of remifentanil and prevent remifentanil induced hyperalgesia. To provide a theoretical basis for clinical multi-mode analgesia.
【作者單位】： 安徽醫(yī)科大學附屬省立醫(yī)院麻醉科;
【基金】：安徽省衛(wèi)生廳中醫(yī)藥科研課題項目(2012zy45)
【分類號】：R614

【參考文獻】

相關期刊論文 前1條

1 張俊海,馮曉源,李霽,湯偉軍,黎元;穴位和非穴位電針鎮(zhèn)痛的腦功能磁共振對照研究[J];中國醫(yī)學計算機成像雜志;2005年01期

【共引文獻】

相關期刊論文 前10條

1 李為民;陳穎波;王曉艷;;手針和電針大鼠“足三里”穴位誘發(fā)的外周傳入神經(jīng)信號特征研究[J];針刺研究;2008年01期

2 楊曉初;何少峰;王仁燦;周詠梅;;溫針灸肌肉刺激療法治療膝骨性關節(jié)炎療效觀察[J];針刺研究;2012年03期

3 胡吳斌;吳子建;汪克明;;中樞5-羥色胺在針刺效應中的作用研究進展[J];針刺研究;2012年03期

4 戴西件;龔洪翰;;功能磁共振成像評價針刺在四肢經(jīng)穴臨床應用的研究進展[J];現(xiàn)代中西醫(yī)結合雜志;2012年07期

5 戴西件;龔洪翰;;功能磁共振成像技術評價針灸臨床療效的研究[J];現(xiàn)代中西醫(yī)結合雜志;2012年08期

6 宋芳;李定忠;;經(jīng)穴挑治治療帶狀皰疹后遺神經(jīng)痛療效觀察[J];中國中醫(yī)藥信息雜志;2009年07期

7 彭浩;彭海東;許玲;;探討雙盲設計在針刺治療癌痛RCT中的可行性——一個小樣本隨機對照雙盲試驗[J];江西中醫(yī)學院學報;2010年04期

8 王小迪;張保國;劉國真;;電針加穴位注射治療腰椎間盤突出癥臨床療效[J];中國運動醫(yī)學雜志;2007年02期

9 郁偉林;李小青;湯偉軍;黎元;李克;翁旭初;陳宜張;;氣功態(tài)時腦運動皮質(zhì)低頻活動同步性的靜息fMRI研究[J];中國醫(yī)學計算機成像雜志;2005年06期

10 張俊海;馮曉源;李克;李霽;曹小定;劉含秋;姚振威;;電針影響交感神經(jīng)活動的腦功能磁共振初步研究[J];中國醫(yī)學計算機成像雜志;2008年02期

【二級參考文獻】

相關期刊論文 前3條

1 陳正秋,吳國冀,徐維;尾核參與大腦皮層對丘腦髓板內(nèi)核群針刺鎮(zhèn)痛的下行性調(diào)節(jié)[J];針刺研究;1997年Z1期

2 劉文彥,白波,王曙光,史為清,葛風,劉玉紅;大鼠中腦導水管周圍灰質(zhì)內(nèi)神經(jīng)降壓素參與針刺鎮(zhèn)痛[J];針刺研究;1997年Z1期

3 侯金文,黃蔚皓,王青,馮Q蔤，

本文編號：2081977