本文選題：帕瑞昔布 + 瑞芬太尼��； 參考：《中外醫(yī)學研究》2016年10期

【摘要】：目的:研究分析帕瑞昔布在瑞芬太尼全身麻醉手術中的臨床效果,為后期的瑞芬太尼全身麻醉手術提供相應的借鑒以及參考。方法:選取2013年12月-2015年2月筆者所在醫(yī)院行全身麻醉手術的患者50例作為研究對象,將其列為帕瑞昔布鎮(zhèn)痛組,進行帕瑞昔布鎮(zhèn)痛。同時選取同期進行全身麻醉手術的患者50例作為生理鹽水鎮(zhèn)痛組,生理鹽水鎮(zhèn)痛組進行等容量生理鹽水鎮(zhèn)痛。在完成手術后對患者的術后疼痛、圍術期炎性水平等進行分析研究,對比兩組患者的效果。結(jié)果:拔管后,帕瑞昔布鎮(zhèn)痛組患者各時間段VAS疼痛評分均明顯低于生理鹽水鎮(zhèn)痛組,差異均有統(tǒng)計學意義(P0.05);鎮(zhèn)痛后帕瑞昔布鎮(zhèn)痛組患者的IL-6水平、IL-8水平均明顯低于生理鹽水鎮(zhèn)痛組,差異均有統(tǒng)計學意義(P0.05),IL-10水平明顯高于生理鹽水鎮(zhèn)痛組,差異有統(tǒng)計學意義(P0.05);兩組患者氣管導管拔除前的評分比較,差異均無統(tǒng)計學意義(P0.05);拔管后10 min評分情況,生理鹽水鎮(zhèn)痛組躁動評分均明顯高于帕瑞昔布鎮(zhèn)痛組,鎮(zhèn)靜評分明顯低于帕瑞昔布鎮(zhèn)痛組,差異均有統(tǒng)計學意義(P0.05)。結(jié)論:使用帕瑞昔布可以促使瑞芬太尼全身麻醉患者的術后疼痛感受有效的降低,可以促使圍術期炎癥因子的水平進一步降低,說明帕瑞昔布在瑞芬太尼全身麻醉手術中具有非常顯著的臨床效果,值得進一步推廣使用。
[Abstract]:Objective: to study the clinical effect of pareoxib in remifentanil general anesthesia, and to provide reference for remifentanil general anesthesia. Methods: 50 patients undergoing general anesthesia operation in our hospital from December 2013 to February 2015 were selected as the study objects, and they were classified as the pareoxib analgesia group for paroxib analgesia. At the same time, 50 patients undergoing general anesthesia were selected as normal saline analgesia group and saline analgesia group. The postoperative pain and perioperative inflammatory level were analyzed and compared between the two groups. Results: after extubation, the VAS pain scores of patients in the pareoxib analgesia group were significantly lower than those in the saline analgesia group. The levels of IL-6 and IL-8 in pareoxib analgesia group were significantly lower than those in saline analgesia group (P0.05), and the level of IL-10 was significantly higher than that in saline analgesia group. The difference was statistically significant (P0.05); there was no significant difference between the two groups before trachea extubation (P0.05); 10 min after extubation, the restlessness score of saline analgesia group was significantly higher than that of pareoxib analgesia group. Sedation score was significantly lower than that of pareoxib analgesia group, the difference was statistically significant (P0.05). Conclusion: the use of pareoxib can effectively reduce postoperative pain perception in patients with remifentanil general anesthesia, and further decrease the level of inflammatory factors in perioperative period. The results suggest that pareoxib has a significant clinical effect in remifentanil general anesthesia, and it is worth further popularizing.
【作者單位】： 張家界市人民醫(yī)院;
【分類號】：R614

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