本文選題：全麻藥物 + 神經(jīng)系統(tǒng)�。� 參考：《臨床麻醉學雜志》2017年12期

【摘要】：正隨著外科技術(shù)進步和手術(shù)量增加,兒童及嬰幼兒接受全麻的數(shù)量也不斷增加,其中不乏新生兒和早產(chǎn)兒。發(fā)育中的大腦對全麻藥物潛在的神經(jīng)毒性十分敏感,早期麻醉暴露可導致神經(jīng)系統(tǒng)遞質(zhì)紊亂、神經(jīng)細胞凋亡變性、突觸和神經(jīng)突結(jié)構(gòu)功能異常、神經(jīng)環(huán)路無法正確形成等[1]。除一過性抑制中樞神經(jīng)系統(tǒng)功能和神經(jīng)傳導外,全麻藥物損傷可能進一步引起長期認知功能和行為改變[2]。以包括非人類靈長目動物在內(nèi)的多個物種為對象的基礎(chǔ)研究結(jié)果表明,
[Abstract]:The number of children and infants receiving general anesthesia, including newborns and premature infants, is increasing as surgery advances and the volume of surgery increases. The developing brain is very sensitive to the potential neurotoxicity of general anesthesia drugs. Early exposure to anesthesia may lead to neurotransmitter disorders, neuronal apoptosis, abnormal synaptic and neuronal structure and function, and the formation of neural loops. In addition to temporary inhibition of central nervous system function and nerve conduction, general anesthesia injury may further cause long-term cognitive and behavioral changes [2]. Basic research on a number of species, including non-human primates, shows that,
【作者單位】： 首都醫(yī)科大學附屬北京天壇醫(yī)院麻醉科;
【基金】：北京市醫(yī)院管理局“揚帆計劃”重點醫(yī)學方向(ZYLX201708) 首都衛(wèi)生發(fā)展科研專項重點攻關(guān)項目(2016-1-20410)
【分類號】：R726.1
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本文編號：1994240