本文選題：恒河猴 + 合谷穴區(qū)　； 參考：《湖南中醫(yī)藥大學》2014年碩士論文

【摘要】：目的：探討恒河猴運動皮層手區(qū)(支配合谷穴區(qū))切除后運動皮層手面區(qū)是否發(fā)生可塑性變化,以及針刺對運動皮層手面區(qū)可塑性的作用。 方法：恒河猴2只,隨機分為自然恢復和針刺治療兩組,動物麻醉后呈俯臥位置于大動物腦立體定位儀上,無菌條件下,行開顱術(shù),于前囟前1cm,向左/右旁開3cm處為中心鉆一1.5×1.5cm2正方形骨窗,暴露腦組織見中央溝和中央前回。采用自制銀球電極刺激運動皮層并同時采用16導電生理記錄儀記錄肌電以確定運動皮層手區(qū)范圍,切除支配手部(支配合谷穴區(qū))肌肉的運動皮層后,待其傷口自然愈合/針刺治療3個月,針刺治療選用華佗牌一次性無菌針灸針(規(guī)格：Φ0.30×25mm,蘇州醫(yī)療器械廠生產(chǎn))刺入恒河猴運動皮層手區(qū)切除對側(cè)的合谷穴和魚際穴,深度15mm,針灸針與穴位皮膚呈90°,采用韓式電針儀(HANS-200A型,南京濟生醫(yī)療科技有限公司)進行電針治療,選擇疏密等幅刺激波形。隔日1次,每次留針20分鐘。觀察運動皮層手/面區(qū)的功能代償情況及針刺的作用。 結(jié)果： 1.自然愈合組和針刺治療組恒河猴在切除運動皮層手區(qū)(合谷穴區(qū))三個月后,刺激與手區(qū)相交界的面區(qū)均可誘導出輕微的對側(cè)拇食指運動,其主要表現(xiàn)為拇指外展或拇食指的顫動,其刺激強度明顯大于切除前手區(qū)誘發(fā)拇食指運動的刺激強度,且伴隨有明顯的面部運動。 2.針刺治療組的恒河猴運動皮層手面區(qū)可塑性變化范圍略大于自然恢復的恒河猴。 結(jié)論： 1.支配手區(qū)(合谷穴區(qū))運動皮層的損傷可導致運動皮層手區(qū)的功能被面區(qū)所替代,其引發(fā)的可塑性變化是漸進性的,且有較明顯的趨向性,即產(chǎn)生手區(qū)和面區(qū)的可塑性變化,而非其他部位。 2.針刺對恒河猴運動皮層手區(qū)(合谷穴區(qū))切除后運動皮層手面區(qū)可塑性變化可能有一定的作用。
[Abstract]:Objective: to investigate the plasticity of hand area of motor cortex of rhesus monkey after excision and the effect of acupuncture on the plasticity of hand area of motor cortex. Methods: two rhesus monkeys were randomly divided into two groups: natural recovery group and acupuncture group. At 1 cm in front of anterior fontanelle, a 1.5 脳 1.5cm2 square bone window was drilled to the left / right side of 3cm. The central sulcus and precentral gyrus were exposed to the brain tissue. The motor cortex was stimulated by a self-made silver ball electrode and the electromyography was recorded with 16 conductive physiological recorder to determine the range of the hand area of the motor cortex and to remove the motor cortex that innervated the muscles of the Hegu acupoint area of the hand. After 3 months of natural wound healing / acupuncture treatment, Huatuo brand sterile acupuncture needle (桅 0.30 脳 25 mm, produced by Suzhou Medical equipment Factory) was used for acupuncture treatment to cut the contralateral Hegu point and thenar point in the hand area of the motor cortex of rhesus monkey. The depth of 15 mm, acupuncture needle and acupoint skin 90 擄, using the Korean electroacupuncture instrument HANS-200A, Nanjing Jisheng Medical Science and Technology Co., Ltd.) electroacupuncture treatment, select density equal amplitude stimulus waveform. Keep the needle for 20 minutes once every other day. To observe the functional compensation of hand / facial area of motor cortex and the effect of acupuncture. Results: 1. In the natural healing group and acupuncture treatment group, three months after the removal of the hand area of motor cortex (Hegu area), the stimulation of the facial area at the junction of the hand area and the hand region could induce slight contralateral thumb forefinger movement. The stimulation intensity of thumb abduction or thumb index finger was significantly higher than that of forefinger movement induced by excision, and accompanied by obvious facial movement. 2. The range of plasticity in the hand area of the motor cortex in the acupuncture treatment group was slightly larger than that in the naturally recovered rhesus monkey. Conclusion: 1. The damage of the motor cortex in the dominant hand area (Hegu acupoint area) can result in the function of the hand region of motor cortex being replaced by the facial area, and the plasticity change caused by the damage is gradual and has obvious tendency, that is to say, the plasticity of the hand area and the plane area is changed. Not other parts. 2. Acupuncture may play a certain role in the plasticity of hand area of motor cortex of rhesus monkey after excision of Hegu area.
【學位授予單位】：湖南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R245

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本文編號：1978202